Depression and schizophrenia: cause, consequence or trans-diagnostic issue?

Research output: Contribution to journalReview articlepeer-review

Authors

External organisations

  • e School of Clinical and Experimental Medicine , Institute of Clinical Sciences , University of Birmingham , Birmingham , UK.
  • The Early Intervention in Psychosis Service, Birmingham and Solihull Mental Health Foundation Trust, Birmingham, UK.
  • Mental Health and Wellbeing, Division of Health Sciences,Warwick Medical School, University of Warwick,Coventry,UK.

Abstract

The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognising depression in schizophrenia bring. Taken together we propose that depression is more than co-morbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.

Details

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalSchizophrenia bulletin
Volume43
Issue number2
Early online date15 Jul 2016
Publication statusPublished - 1 Mar 2017

Keywords

  • Comorbidity, Depressive Disorder/epidemiology, Humans, Psychotic Disorders/complications, Schizophrenia/complications