Abstract
We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4-51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes.
| Original language | English |
|---|---|
| Pages (from-to) | 1019-1032 |
| Number of pages | 14 |
| Journal | Journal of Autism and Developmental Disorders |
| Volume | 41 |
| Issue number | 8 |
| Early online date | 16 Nov 2010 |
| DOIs | |
| Publication status | Published - Aug 2011 |
Keywords
- Affect
- Autism spectrum disorder
- Behavioral phenotype
- Genetic syndromes
- Hyperactivity
- Impulsivity
- adolescent
- adult
- affect
- article
- autism
- behavior
- cat cry syndrome
- child
- de Lange syndrome
- female
- fragile X syndrome
- happy puppet syndrome
- human
- hyperactivity
- impulsiveness
- Lowe syndrome
- major clinical study
- male
- phenotype
- Prader Willi syndrome
- preschool child
- priority journal
- school child
- scoring system
- Smith Magenis syndrome
- symptomatology
- syndrome delineation
- Adolescent
- Adult
- Child
- Child Development Disorders, Pervasive
- Child, Preschool
- Chromosome Disorders
- Female
- Humans
- Hyperkinesis
- Male
- Middle Aged
- Phenotype