Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity

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@article{aa71b7c9124f43118eafaf629617d918,
title = "Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity",
abstract = "We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4-51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes.",
keywords = "Affect, Autism spectrum disorder, Behavioral phenotype, Genetic syndromes, Hyperactivity, Impulsivity, adolescent, adult, affect, article, autism, behavior, cat cry syndrome, child, de Lange syndrome, female, fragile X syndrome, happy puppet syndrome, human, hyperactivity, impulsiveness, Lowe syndrome, major clinical study, male, phenotype, Prader Willi syndrome, preschool child, priority journal, school child, scoring system, Smith Magenis syndrome, symptomatology, syndrome delineation, Adolescent, Adult, Child, Child Development Disorders, Pervasive, Child, Preschool, Chromosome Disorders, Female, Humans, Hyperkinesis, Male, Middle Aged, Phenotype",
author = "C. Oliver and K. Berg and J. Moss and K. Arron and C. Burbidge",
year = "2011",
month = "8",
doi = "10.1007/s10803-010-1125-5",
language = "English",
volume = "41",
pages = "1019--1032",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Delineation of Behavioral Phenotypes in Genetic Syndromes

T2 - Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity

AU - Oliver, C.

AU - Berg, K.

AU - Moss, J.

AU - Arron, K.

AU - Burbidge, C.

PY - 2011/8

Y1 - 2011/8

N2 - We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4-51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes.

AB - We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4-51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes.

KW - Affect

KW - Autism spectrum disorder

KW - Behavioral phenotype

KW - Genetic syndromes

KW - Hyperactivity

KW - Impulsivity

KW - adolescent

KW - adult

KW - affect

KW - article

KW - autism

KW - behavior

KW - cat cry syndrome

KW - child

KW - de Lange syndrome

KW - female

KW - fragile X syndrome

KW - happy puppet syndrome

KW - human

KW - hyperactivity

KW - impulsiveness

KW - Lowe syndrome

KW - major clinical study

KW - male

KW - phenotype

KW - Prader Willi syndrome

KW - preschool child

KW - priority journal

KW - school child

KW - scoring system

KW - Smith Magenis syndrome

KW - symptomatology

KW - syndrome delineation

KW - Adolescent

KW - Adult

KW - Child

KW - Child Development Disorders, Pervasive

KW - Child, Preschool

KW - Chromosome Disorders

KW - Female

KW - Humans

KW - Hyperkinesis

KW - Male

KW - Middle Aged

KW - Phenotype

U2 - 10.1007/s10803-010-1125-5

DO - 10.1007/s10803-010-1125-5

M3 - Article

VL - 41

SP - 1019

EP - 1032

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

IS - 8

ER -