Delineating the profile of autism spectrum disorder characteristics in Cornelia de Lange and fragile x syndromes: American Journal on Intellectual and Developmental Disabilities

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@article{5ae870d5fed54531939b9f9a5b817f07,
title = "Delineating the profile of autism spectrum disorder characteristics in Cornelia de Lange and fragile x syndromes: American Journal on Intellectual and Developmental Disabilities",
abstract = "Abstract An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n = 130, M age = 17.19), Fragile X syndrome (n = 182, M age = 16.94), and autism spectrum disorder (n = 142, M age = 15.19), who were comparable on chronological age. Using the Social Communication Questionnaire, the proportion meeting cutoff for autism spectrum disorder and autism was 78.6%, and 45.6%, respectively, in Cornelia de Lange syndrome and 83.6% and 48.6% in Fragile X syndrome. Domain and item analyses indicate differing, atypical autism spectrum disorder profiles in Fragile X and Cornelia de Lange syndromes. A limited association between adaptive behavior and autism spectrum disorder was identified in all groups. The findings have implications for intervention in genetic syndromes and conceptualization of autism spectrum disorder in the wider population. {\textcopyright} EAAIDD.",
keywords = "Autism spectrum disorder, Behavioral phenotypes, Cornelia de Lange syndrome, Fragile X syndrome, adaptive behavior, adolescent, adult, article, autism, child, classification, comorbidity, de Lange syndrome, disability, female, fragile X syndrome, human, interpersonal communication, male, preschool child, psychological aspect, questionnaire, self care, social adaptation, Adaptation, Psychological, Adolescent, Adult, Child, Child Development Disorders, Pervasive, Child, Preschool, Communication, Comorbidity, De Lange Syndrome, Disability Evaluation, Female, Fragile X Syndrome, Humans, Male, Questionnaires, Self Care, Social Adjustment, Young Adult",
author = "J. Moss and C. Oliver and L. Nelson and C. Richards and S. Hall",
year = "2013",
month = jan,
doi = "10.1352/1944-7558-118.1.55",
language = "English",
volume = "118",
pages = "55--73",
journal = "American Journal on Intellectual and Developmental Disabilities",
issn = "1944-7515",
publisher = "American Association on Intellectual and Developmental Disabilities",
number = "1",

}

RIS

TY - JOUR

T1 - Delineating the profile of autism spectrum disorder characteristics in Cornelia de Lange and fragile x syndromes

T2 - American Journal on Intellectual and Developmental Disabilities

AU - Moss, J.

AU - Oliver, C.

AU - Nelson, L.

AU - Richards, C.

AU - Hall, S.

PY - 2013/1

Y1 - 2013/1

N2 - Abstract An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n = 130, M age = 17.19), Fragile X syndrome (n = 182, M age = 16.94), and autism spectrum disorder (n = 142, M age = 15.19), who were comparable on chronological age. Using the Social Communication Questionnaire, the proportion meeting cutoff for autism spectrum disorder and autism was 78.6%, and 45.6%, respectively, in Cornelia de Lange syndrome and 83.6% and 48.6% in Fragile X syndrome. Domain and item analyses indicate differing, atypical autism spectrum disorder profiles in Fragile X and Cornelia de Lange syndromes. A limited association between adaptive behavior and autism spectrum disorder was identified in all groups. The findings have implications for intervention in genetic syndromes and conceptualization of autism spectrum disorder in the wider population. © EAAIDD.

AB - Abstract An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n = 130, M age = 17.19), Fragile X syndrome (n = 182, M age = 16.94), and autism spectrum disorder (n = 142, M age = 15.19), who were comparable on chronological age. Using the Social Communication Questionnaire, the proportion meeting cutoff for autism spectrum disorder and autism was 78.6%, and 45.6%, respectively, in Cornelia de Lange syndrome and 83.6% and 48.6% in Fragile X syndrome. Domain and item analyses indicate differing, atypical autism spectrum disorder profiles in Fragile X and Cornelia de Lange syndromes. A limited association between adaptive behavior and autism spectrum disorder was identified in all groups. The findings have implications for intervention in genetic syndromes and conceptualization of autism spectrum disorder in the wider population. © EAAIDD.

KW - Autism spectrum disorder

KW - Behavioral phenotypes

KW - Cornelia de Lange syndrome

KW - Fragile X syndrome

KW - adaptive behavior

KW - adolescent

KW - adult

KW - article

KW - autism

KW - child

KW - classification

KW - comorbidity

KW - de Lange syndrome

KW - disability

KW - female

KW - fragile X syndrome

KW - human

KW - interpersonal communication

KW - male

KW - preschool child

KW - psychological aspect

KW - questionnaire

KW - self care

KW - social adaptation

KW - Adaptation, Psychological

KW - Adolescent

KW - Adult

KW - Child

KW - Child Development Disorders, Pervasive

KW - Child, Preschool

KW - Communication

KW - Comorbidity

KW - De Lange Syndrome

KW - Disability Evaluation

KW - Female

KW - Fragile X Syndrome

KW - Humans

KW - Male

KW - Questionnaires

KW - Self Care

KW - Social Adjustment

KW - Young Adult

U2 - 10.1352/1944-7558-118.1.55

DO - 10.1352/1944-7558-118.1.55

M3 - Article

C2 - 23301903

VL - 118

SP - 55

EP - 73

JO - American Journal on Intellectual and Developmental Disabilities

JF - American Journal on Intellectual and Developmental Disabilities

SN - 1944-7515

IS - 1

ER -