Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization

Rebecca J. Williams; Rachel K. O'Reilly; Andrew P. Dove

doi:10.1039/c2py20213a

Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization

Rebecca J. Williams, Rachel K. O'Reilly, Andrew P. Dove

Chemistry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition–fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.

Original language	English
Pages (from-to)	2156-2164
Journal	Polymer Chemistry
Volume	3
Issue number	18
DOIs	https://doi.org/10.1039/c2py20213a
Publication status	Published - 24 May 2012

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abstract = "The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition–fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.",

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AU - Dove, Andrew P.

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N2 - The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition–fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.

AB - The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition–fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.

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EP - 2164

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 18

ER -

Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization

Abstract

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