Deformation and rupture of compound cells under shear: A discrete multiphysics study
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Authors
Colleges, School and Institutes
Abstract
This paper develops a three-dimensional numerical model for the simulation of cells in simple shear flow. The model is based on Discrete Multi-Physics (DMP), a meshless particle-based method that couples the smoothed particle hydrodynamics and the mass-spring model. In this study, the effect of the nucleus in cells is investigated for a broad range of capillary numbers. It is shown that the nucleus size affects the deformation of the cell. Moreover, oscillations are observed in the tank-treading motion of the membrane when capillary number and nucleus size are both sufficiently large. Additionally, DMP shows that the cell and nuclei may experience rupture under extreme flow conditions.
Details
Original language | English |
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Article number | 051903 |
Journal | Physics of Fluids |
Volume | 31 |
Issue number | 5 |
Publication status | Published - 1 May 2019 |