Abstract
The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development.
| Original language | English |
|---|---|
| Pages (from-to) | 2-6 |
| Number of pages | 5 |
| Journal | Nature Cell Biology |
| Volume | 9 |
| DOIs | |
| Publication status | Published - 1 Jan 2007 |