Defining an epigenetic code

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development.

Details

Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalNature Cell Biology
Volume9
Publication statusPublished - 1 Jan 2007