Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease

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@article{57fa9da77a4348439abebe9c5c47cc40,
title = "Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease",
abstract = "The most surprising feature of the inflammatory response in rheumatoid arthritis is not that it occurs but that it does not resolve. The persistence of the chronic inflammatory response in conjunction with ongoing joint destruction is an all too familiar finding in many patients with rheumatoid arthritis. Despite the use of effective anti-inflammatory agents and disease modifying drugs, a significant proportion of patients with rheumatoid arthritis continue to have resistant disease. Complete clinical remission is unusual for more than six months and a formal cure of the disease remains elusive. In this report we focus on how attempts to address the question of why rheumatoid arthritis persists have led to a different interpretation of the pathogenesis of rheumatoid disease; one in which alterations in stromal cells such as fibroblasts play an important role in the switch from resolving to persistent disease.",
author = "Christopher Buckley and Andrew Filer and Oliver Haworth and Gregory Parsonage and Karim Raza and Michael Salmon",
year = "2004",
month = jan,
day = "1",
doi = "10.1136/ard.2004.028332",
language = "English",
volume = "63",
pages = "ii92--ii95",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",

}

RIS

TY - JOUR

T1 - Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease

AU - Buckley, Christopher

AU - Filer, Andrew

AU - Haworth, Oliver

AU - Parsonage, Gregory

AU - Raza, Karim

AU - Salmon, Michael

PY - 2004/1/1

Y1 - 2004/1/1

N2 - The most surprising feature of the inflammatory response in rheumatoid arthritis is not that it occurs but that it does not resolve. The persistence of the chronic inflammatory response in conjunction with ongoing joint destruction is an all too familiar finding in many patients with rheumatoid arthritis. Despite the use of effective anti-inflammatory agents and disease modifying drugs, a significant proportion of patients with rheumatoid arthritis continue to have resistant disease. Complete clinical remission is unusual for more than six months and a formal cure of the disease remains elusive. In this report we focus on how attempts to address the question of why rheumatoid arthritis persists have led to a different interpretation of the pathogenesis of rheumatoid disease; one in which alterations in stromal cells such as fibroblasts play an important role in the switch from resolving to persistent disease.

AB - The most surprising feature of the inflammatory response in rheumatoid arthritis is not that it occurs but that it does not resolve. The persistence of the chronic inflammatory response in conjunction with ongoing joint destruction is an all too familiar finding in many patients with rheumatoid arthritis. Despite the use of effective anti-inflammatory agents and disease modifying drugs, a significant proportion of patients with rheumatoid arthritis continue to have resistant disease. Complete clinical remission is unusual for more than six months and a formal cure of the disease remains elusive. In this report we focus on how attempts to address the question of why rheumatoid arthritis persists have led to a different interpretation of the pathogenesis of rheumatoid disease; one in which alterations in stromal cells such as fibroblasts play an important role in the switch from resolving to persistent disease.

U2 - 10.1136/ard.2004.028332

DO - 10.1136/ard.2004.028332

M3 - Abstract

VL - 63

SP - ii92-ii95

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -