Deep brain stimulation for tremor resulting from acquired brain injury

Research output: Contribution to journalArticle


  • H A Sitsapesan
  • P Holland
  • Z Oliphant
  • N De Pennington
  • C Joint
  • T Z Aziz
  • A L Green


OBJECTIVES: To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).

METHODS: A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.

RESULTS: VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.

CONCLUSION: VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.

Bibliographic note

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Original languageEnglish
Pages (from-to)811-5
Number of pages5
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number7
Publication statusPublished - Jul 2014


  • Adult, Aged, Brain Injuries, Deep Brain Stimulation, Electrodes, Implanted, Female, Humans, Male, Severity of Illness Index, Single-Blind Method, Treatment Outcome, Tremor, Young Adult