Deep brain stimulation for tremor resulting from acquired brain injury
Research output: Contribution to journal › Article
OBJECTIVES: To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).
METHODS: A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.
RESULTS: VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.
CONCLUSION: VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.
|Number of pages||5|
|Journal||Journal of Neurology Neurosurgery and Psychiatry|
|Publication status||Published - Jul 2014|
- Adult, Aged, Brain Injuries, Deep Brain Stimulation, Electrodes, Implanted, Female, Humans, Male, Severity of Illness Index, Single-Blind Method, Treatment Outcome, Tremor, Young Adult