Decreased visfatin after exercise training correlates with improved glucose tolerance

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Decreased visfatin after exercise training correlates with improved glucose tolerance. / Haus, Jacob M; Solomon, Thomas P J; Marchetti, Christine M; O'Leary, Valerie B; Brooks, Latina M; Gonzalez, Frank; Kirwan, John P.

In: Medicine and Science in Sports and Exercise, Vol. 41, No. 6, 06.2009, p. 1255-60.

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Haus, Jacob M ; Solomon, Thomas P J ; Marchetti, Christine M ; O'Leary, Valerie B ; Brooks, Latina M ; Gonzalez, Frank ; Kirwan, John P. / Decreased visfatin after exercise training correlates with improved glucose tolerance. In: Medicine and Science in Sports and Exercise. 2009 ; Vol. 41, No. 6. pp. 1255-60.

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@article{6fc3cc1c7acf48d4be37ef1d91bfcd03,
title = "Decreased visfatin after exercise training correlates with improved glucose tolerance",
abstract = "UNLABELLED: Nampt/pre-B-cell colony-enhancing factor/visfatin (visfatin) release from adipocytes has recently been suggested to be nutrient responsive and linked to systemic nicotinamide adenine dinucleotide biosynthesis and regulation of pancreatic beta-cell function.PURPOSE: We hypothesized that if visfatin does play a role in the insulin response, then the exercise training-induced reduction in insulin response to an oral glucose load would correlate with reduced plasma visfatin.METHODS: Sixteen obese men and women (age = 65 +/- 1 yr, body mass index = 33.4 +/- 1.5 kg x m(-2)) volunteered to participate in a 12-wk supervised exercise program (5 d x wk(-1), 60 min x d(-1) at 85% of HRmax). Visceral (VAT) and subcutaneous adipose tissue (SAT) were measured by computed tomographic scans. A 2-h 75-g oral glucose tolerance test was performed to determine the effect of exercise training on the insulin response to a glucose load. Fasting plasma visfatin was measured by enzyme-linked immunosorbent assay.RESULTS: Exercise training resulted in an increase in (.)VO2max (21.1 +/- 0.9 vs 24.2 +/- 1.1 mL x kg(-1) x min(-1), P < 0.001), a decrease in body weight (96.4 +/- 4.1 vs 92.4 +/- 3.7 kg, P < 0.001), VAT (191 +/- 16 vs 144 +/- 16 cm, P < 0.001), and SAT (369 +/- 34 vs 309 +/- 41 cm, P < 0.02). Area under the glucose (450 +/- 31 vs 392 +/- 33 mmol x L(-1) x 2 h(-1), P < 0.01) and insulin (45,767 +/- 6142 vs 35,277 +/- 4997 pmol x L(-1) x 2 h(-1), P < 0.003) response curves were decreased after training. After intervention, plasma visfatin levels were significantly reduced (16.9 +/- 2.2 vs 14.5 +/- 1.8 ng x mL(-1), P < 0.05), and the change in visfatin was associated with the corresponding change in insulin (r = 0.56, P < 0.05) and glucose AUC (r = 0.53, P < 0.05).CONCLUSION: The exercise-induced reduction of plasma visfatin is most likely the result of weight loss and body composition changes. The potential regulatory role of visfatin in mediating the pancreatic insulin response to oral glucose requires further investigation.",
keywords = "Adipokines, Aged, Blood Glucose, Exercise, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Intra-Abdominal Fat, Male, Motor Activity, Nicotinamide Phosphoribosyltransferase, Obesity, Physical Fitness, Statistics as Topic",
author = "Haus, {Jacob M} and Solomon, {Thomas P J} and Marchetti, {Christine M} and O'Leary, {Valerie B} and Brooks, {Latina M} and Frank Gonzalez and Kirwan, {John P}",
year = "2009",
month = jun,
doi = "10.1249/MSS.0b013e318195bad5",
language = "English",
volume = "41",
pages = "1255--60",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "American College of Sports Medicine",
number = "6",

}

RIS

TY - JOUR

T1 - Decreased visfatin after exercise training correlates with improved glucose tolerance

AU - Haus, Jacob M

AU - Solomon, Thomas P J

AU - Marchetti, Christine M

AU - O'Leary, Valerie B

AU - Brooks, Latina M

AU - Gonzalez, Frank

AU - Kirwan, John P

PY - 2009/6

Y1 - 2009/6

N2 - UNLABELLED: Nampt/pre-B-cell colony-enhancing factor/visfatin (visfatin) release from adipocytes has recently been suggested to be nutrient responsive and linked to systemic nicotinamide adenine dinucleotide biosynthesis and regulation of pancreatic beta-cell function.PURPOSE: We hypothesized that if visfatin does play a role in the insulin response, then the exercise training-induced reduction in insulin response to an oral glucose load would correlate with reduced plasma visfatin.METHODS: Sixteen obese men and women (age = 65 +/- 1 yr, body mass index = 33.4 +/- 1.5 kg x m(-2)) volunteered to participate in a 12-wk supervised exercise program (5 d x wk(-1), 60 min x d(-1) at 85% of HRmax). Visceral (VAT) and subcutaneous adipose tissue (SAT) were measured by computed tomographic scans. A 2-h 75-g oral glucose tolerance test was performed to determine the effect of exercise training on the insulin response to a glucose load. Fasting plasma visfatin was measured by enzyme-linked immunosorbent assay.RESULTS: Exercise training resulted in an increase in (.)VO2max (21.1 +/- 0.9 vs 24.2 +/- 1.1 mL x kg(-1) x min(-1), P < 0.001), a decrease in body weight (96.4 +/- 4.1 vs 92.4 +/- 3.7 kg, P < 0.001), VAT (191 +/- 16 vs 144 +/- 16 cm, P < 0.001), and SAT (369 +/- 34 vs 309 +/- 41 cm, P < 0.02). Area under the glucose (450 +/- 31 vs 392 +/- 33 mmol x L(-1) x 2 h(-1), P < 0.01) and insulin (45,767 +/- 6142 vs 35,277 +/- 4997 pmol x L(-1) x 2 h(-1), P < 0.003) response curves were decreased after training. After intervention, plasma visfatin levels were significantly reduced (16.9 +/- 2.2 vs 14.5 +/- 1.8 ng x mL(-1), P < 0.05), and the change in visfatin was associated with the corresponding change in insulin (r = 0.56, P < 0.05) and glucose AUC (r = 0.53, P < 0.05).CONCLUSION: The exercise-induced reduction of plasma visfatin is most likely the result of weight loss and body composition changes. The potential regulatory role of visfatin in mediating the pancreatic insulin response to oral glucose requires further investigation.

AB - UNLABELLED: Nampt/pre-B-cell colony-enhancing factor/visfatin (visfatin) release from adipocytes has recently been suggested to be nutrient responsive and linked to systemic nicotinamide adenine dinucleotide biosynthesis and regulation of pancreatic beta-cell function.PURPOSE: We hypothesized that if visfatin does play a role in the insulin response, then the exercise training-induced reduction in insulin response to an oral glucose load would correlate with reduced plasma visfatin.METHODS: Sixteen obese men and women (age = 65 +/- 1 yr, body mass index = 33.4 +/- 1.5 kg x m(-2)) volunteered to participate in a 12-wk supervised exercise program (5 d x wk(-1), 60 min x d(-1) at 85% of HRmax). Visceral (VAT) and subcutaneous adipose tissue (SAT) were measured by computed tomographic scans. A 2-h 75-g oral glucose tolerance test was performed to determine the effect of exercise training on the insulin response to a glucose load. Fasting plasma visfatin was measured by enzyme-linked immunosorbent assay.RESULTS: Exercise training resulted in an increase in (.)VO2max (21.1 +/- 0.9 vs 24.2 +/- 1.1 mL x kg(-1) x min(-1), P < 0.001), a decrease in body weight (96.4 +/- 4.1 vs 92.4 +/- 3.7 kg, P < 0.001), VAT (191 +/- 16 vs 144 +/- 16 cm, P < 0.001), and SAT (369 +/- 34 vs 309 +/- 41 cm, P < 0.02). Area under the glucose (450 +/- 31 vs 392 +/- 33 mmol x L(-1) x 2 h(-1), P < 0.01) and insulin (45,767 +/- 6142 vs 35,277 +/- 4997 pmol x L(-1) x 2 h(-1), P < 0.003) response curves were decreased after training. After intervention, plasma visfatin levels were significantly reduced (16.9 +/- 2.2 vs 14.5 +/- 1.8 ng x mL(-1), P < 0.05), and the change in visfatin was associated with the corresponding change in insulin (r = 0.56, P < 0.05) and glucose AUC (r = 0.53, P < 0.05).CONCLUSION: The exercise-induced reduction of plasma visfatin is most likely the result of weight loss and body composition changes. The potential regulatory role of visfatin in mediating the pancreatic insulin response to oral glucose requires further investigation.

KW - Adipokines

KW - Aged

KW - Blood Glucose

KW - Exercise

KW - Female

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin Resistance

KW - Intra-Abdominal Fat

KW - Male

KW - Motor Activity

KW - Nicotinamide Phosphoribosyltransferase

KW - Obesity

KW - Physical Fitness

KW - Statistics as Topic

U2 - 10.1249/MSS.0b013e318195bad5

DO - 10.1249/MSS.0b013e318195bad5

M3 - Article

C2 - 19461540

VL - 41

SP - 1255

EP - 1260

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 6

ER -