Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging

Research output: Contribution to journalArticle

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Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging. / Agius, E; Lacy, KE; Vukmanovic-Stejic, M; Jagger, AL; Papageorgiou, AP; Hall, S; Reed, JR; Curnow, Stephen; Fuentes-Duculan, J; Buckley, Christopher; Salmon, M; Taams, LS; Krueger, J; Greenwood, J; Klein, N; Rustin, MHA; Akbar, AN.

In: The Journal of Experimental Medicine, Vol. 206, No. 9, 01.08.2009, p. 1929-1940.

Research output: Contribution to journalArticle

Harvard

Agius, E, Lacy, KE, Vukmanovic-Stejic, M, Jagger, AL, Papageorgiou, AP, Hall, S, Reed, JR, Curnow, S, Fuentes-Duculan, J, Buckley, C, Salmon, M, Taams, LS, Krueger, J, Greenwood, J, Klein, N, Rustin, MHA & Akbar, AN 2009, 'Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging', The Journal of Experimental Medicine, vol. 206, no. 9, pp. 1929-1940. https://doi.org/10.1084/jem.20090896

APA

Agius, E., Lacy, KE., Vukmanovic-Stejic, M., Jagger, AL., Papageorgiou, AP., Hall, S., Reed, JR., Curnow, S., Fuentes-Duculan, J., Buckley, C., Salmon, M., Taams, LS., Krueger, J., Greenwood, J., Klein, N., Rustin, MHA., & Akbar, AN. (2009). Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging. The Journal of Experimental Medicine, 206(9), 1929-1940. https://doi.org/10.1084/jem.20090896

Vancouver

Author

Agius, E ; Lacy, KE ; Vukmanovic-Stejic, M ; Jagger, AL ; Papageorgiou, AP ; Hall, S ; Reed, JR ; Curnow, Stephen ; Fuentes-Duculan, J ; Buckley, Christopher ; Salmon, M ; Taams, LS ; Krueger, J ; Greenwood, J ; Klein, N ; Rustin, MHA ; Akbar, AN. / Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging. In: The Journal of Experimental Medicine. 2009 ; Vol. 206, No. 9. pp. 1929-1940.

Bibtex

@article{4a06b23399814e6ab27cdcbe95e51b68,
title = "Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging",
abstract = "Immunity declines during aging, however the mechanisms involved in this decline are not known. In this study, we show that cutaneous delayed type hypersensitivity (DTH) responses to recall antigens are significantly decreased in older individuals. However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated antigen, or CD11a expression by CD4(+) T cells or their physical capacity for migration. Instead, there is defective activation of dermal blood vessels in older subject that results from decreased TNF-alpha secretion by macrophages. This prevents memory T cell entry into the skin after antigen challenge. However, isolated cutaneous macrophages from these subjects can be induced to secrete TNF-alpha after stimulation with Toll-like receptor (TLR) 1/2 or TLR 4 ligands in vitro, indicating that the defect is reversible. The decreased conditioning of tissue microenvironments by macrophage-derived cytokines may therefore lead to defective immunosurveillance by memory T cells. This may be a predisposing factor for the development of malignancy and infection in the skin during aging.",
author = "E Agius and KE Lacy and M Vukmanovic-Stejic and AL Jagger and AP Papageorgiou and S Hall and JR Reed and Stephen Curnow and J Fuentes-Duculan and Christopher Buckley and M Salmon and LS Taams and J Krueger and J Greenwood and N Klein and MHA Rustin and AN Akbar",
year = "2009",
month = aug,
day = "1",
doi = "10.1084/jem.20090896",
language = "English",
volume = "206",
pages = "1929--1940",
journal = "The Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging

AU - Agius, E

AU - Lacy, KE

AU - Vukmanovic-Stejic, M

AU - Jagger, AL

AU - Papageorgiou, AP

AU - Hall, S

AU - Reed, JR

AU - Curnow, Stephen

AU - Fuentes-Duculan, J

AU - Buckley, Christopher

AU - Salmon, M

AU - Taams, LS

AU - Krueger, J

AU - Greenwood, J

AU - Klein, N

AU - Rustin, MHA

AU - Akbar, AN

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Immunity declines during aging, however the mechanisms involved in this decline are not known. In this study, we show that cutaneous delayed type hypersensitivity (DTH) responses to recall antigens are significantly decreased in older individuals. However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated antigen, or CD11a expression by CD4(+) T cells or their physical capacity for migration. Instead, there is defective activation of dermal blood vessels in older subject that results from decreased TNF-alpha secretion by macrophages. This prevents memory T cell entry into the skin after antigen challenge. However, isolated cutaneous macrophages from these subjects can be induced to secrete TNF-alpha after stimulation with Toll-like receptor (TLR) 1/2 or TLR 4 ligands in vitro, indicating that the defect is reversible. The decreased conditioning of tissue microenvironments by macrophage-derived cytokines may therefore lead to defective immunosurveillance by memory T cells. This may be a predisposing factor for the development of malignancy and infection in the skin during aging.

AB - Immunity declines during aging, however the mechanisms involved in this decline are not known. In this study, we show that cutaneous delayed type hypersensitivity (DTH) responses to recall antigens are significantly decreased in older individuals. However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated antigen, or CD11a expression by CD4(+) T cells or their physical capacity for migration. Instead, there is defective activation of dermal blood vessels in older subject that results from decreased TNF-alpha secretion by macrophages. This prevents memory T cell entry into the skin after antigen challenge. However, isolated cutaneous macrophages from these subjects can be induced to secrete TNF-alpha after stimulation with Toll-like receptor (TLR) 1/2 or TLR 4 ligands in vitro, indicating that the defect is reversible. The decreased conditioning of tissue microenvironments by macrophage-derived cytokines may therefore lead to defective immunosurveillance by memory T cells. This may be a predisposing factor for the development of malignancy and infection in the skin during aging.

U2 - 10.1084/jem.20090896

DO - 10.1084/jem.20090896

M3 - Article

C2 - 19667063

VL - 206

SP - 1929

EP - 1940

JO - The Journal of Experimental Medicine

JF - The Journal of Experimental Medicine

SN - 0022-1007

IS - 9

ER -