Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis

Benjamin Fisher; Andrew Filer; Christopher Buckley

Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis

Benjamin Fisher, Andrew Filer, Christopher Buckley

Inflammation and Ageing

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: An important feature of RA is hypoxia-driven synovial angiogenesis, but the relationship between change in vascularity, as measured by power Doppler ultrasound (PDUS), and oxygen tensions is unaddressed.
Methods: MCP joint PDUS was assessed in 23 patients with RA, alongside arthroscopic synovitis and oxygen tension measurements, at baseline and 4 weeks after anti-TNF.
Results: Anti-TNF reduced PDUS scores, which were negatively correlated with rise in oxygen tensions. The latter was related to good EULAR response at week 52.
Conclusion: Anti-TNF results in rapid reduction in synovial blood flow, with a corresponding rise in oxygen tension most marked in EULAR good responders.

Original language	English
Journal	Clinical and Experimental Rheumatology
Publication status	Accepted/In press - 30 May 2016

Keywords

tumour necrosis factor inhibitors
rheumatoid arthritis
ultrasonography
synovium

Cite this

@article{12c8538063364285a809a7385809ef3d,

title = "Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis",

abstract = "Objective: An important feature of RA is hypoxia-driven synovial angiogenesis, but the relationship between change in vascularity, as measured by power Doppler ultrasound (PDUS), and oxygen tensions is unaddressed. Methods: MCP joint PDUS was assessed in 23 patients with RA, alongside arthroscopic synovitis and oxygen tension measurements, at baseline and 4 weeks after anti-TNF. Results: Anti-TNF reduced PDUS scores, which were negatively correlated with rise in oxygen tensions. The latter was related to good EULAR response at week 52.Conclusion: Anti-TNF results in rapid reduction in synovial blood flow, with a corresponding rise in oxygen tension most marked in EULAR good responders.",

keywords = "tumour necrosis factor inhibitors, rheumatoid arthritis, ultrasonography, synovium",

author = "Benjamin Fisher and Andrew Filer and Christopher Buckley",

year = "2016",

month = may,

day = "30",

language = "English",

journal = "Clinical and Experimental Rheumatology",

issn = "0392-856X",

publisher = "Clinical and Experimental Rheumatology S.A.S.",

}

TY - JOUR

T1 - Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis

AU - Fisher, Benjamin

AU - Filer, Andrew

AU - Buckley, Christopher

PY - 2016/5/30

Y1 - 2016/5/30

N2 - Objective: An important feature of RA is hypoxia-driven synovial angiogenesis, but the relationship between change in vascularity, as measured by power Doppler ultrasound (PDUS), and oxygen tensions is unaddressed. Methods: MCP joint PDUS was assessed in 23 patients with RA, alongside arthroscopic synovitis and oxygen tension measurements, at baseline and 4 weeks after anti-TNF. Results: Anti-TNF reduced PDUS scores, which were negatively correlated with rise in oxygen tensions. The latter was related to good EULAR response at week 52.Conclusion: Anti-TNF results in rapid reduction in synovial blood flow, with a corresponding rise in oxygen tension most marked in EULAR good responders.

AB - Objective: An important feature of RA is hypoxia-driven synovial angiogenesis, but the relationship between change in vascularity, as measured by power Doppler ultrasound (PDUS), and oxygen tensions is unaddressed. Methods: MCP joint PDUS was assessed in 23 patients with RA, alongside arthroscopic synovitis and oxygen tension measurements, at baseline and 4 weeks after anti-TNF. Results: Anti-TNF reduced PDUS scores, which were negatively correlated with rise in oxygen tensions. The latter was related to good EULAR response at week 52.Conclusion: Anti-TNF results in rapid reduction in synovial blood flow, with a corresponding rise in oxygen tension most marked in EULAR good responders.

KW - tumour necrosis factor inhibitors

KW - rheumatoid arthritis

KW - ultrasonography

KW - synovium

M3 - Article

SN - 0392-856X

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

ER -

Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis

Abstract

Keywords

Fingerprint

Cite this