Decorin treatment of spinal cord injury

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Decorin treatment of spinal cord injury. / Esmaeili, Maryam; Berry, Martin; Logan, Ann; Ahmed, Zubair.

In: Neural Regeneration Research, Vol. 9, No. 18, 15.09.2014, p. 1653-6.

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@article{c96b863cce88443b99c0b3fb2e61b28c,
title = "Decorin treatment of spinal cord injury",
abstract = "The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.",
author = "Maryam Esmaeili and Martin Berry and Ann Logan and Zubair Ahmed",
year = "2014",
month = sep,
day = "15",
doi = "10.4103/1673-5374.141797",
language = "English",
volume = "9",
pages = "1653--6",
journal = "Neural Regeneration Research",
issn = "1673-5374",
publisher = "Editorial Board of Neural Regeneration Research",
number = "18",

}

RIS

TY - JOUR

T1 - Decorin treatment of spinal cord injury

AU - Esmaeili, Maryam

AU - Berry, Martin

AU - Logan, Ann

AU - Ahmed, Zubair

PY - 2014/9/15

Y1 - 2014/9/15

N2 - The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.

AB - The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.

U2 - 10.4103/1673-5374.141797

DO - 10.4103/1673-5374.141797

M3 - Article

C2 - 25374584

VL - 9

SP - 1653

EP - 1656

JO - Neural Regeneration Research

JF - Neural Regeneration Research

SN - 1673-5374

IS - 18

ER -