Decorin treatment of spinal cord injury

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.

Details

Original languageEnglish
Pages (from-to)1653-6
Number of pages4
JournalNeural Regeneration Research
Volume9
Issue number18
Publication statusPublished - 15 Sep 2014