De novo designed imaging agents based on lanthanide peptides complexes

Research output: Chapter in Book/Report/Conference proceedingChapter

Authors

Colleges, School and Institutes

Abstract

Herein are discussed a selection of lanthanide peptide/protein complexes in view of their potential applications as imaging agents, both in terms of luminescence detection and magnetic resonance imaging. Though this chapter covers a range of different peptides and protein, if focuses specifically on the opportunities afforded by the de novo design of coiled coils, miniature protein scaffolds, and the development on lanthanide-binding sites into these architectures. The requirements for lanthanide coordination and the challenges that need to be addressed when preparing lanthanide peptides with a view to their potential adoption as clinical imaging applications, will be highlighted.

Details

Original languageEnglish
Title of host publicationPeptide, Protein and Enzyme Design
EditorsVincent L. Pecoraro
Publication statusPublished - 9 Sep 2016

Publication series

NameMethods in Enzymology
Volume580
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • Coiled coils, Coordination chemistry, De novo design, Gadolinium, Imaging, Lanthanide, Luminescence, MRI, Peptide

ASJC Scopus subject areas