De novo designed imaging agents based on lanthanide peptides complexes

A. F.A. Peacock*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Herein are discussed a selection of lanthanide peptide/protein complexes in view of their potential applications as imaging agents, both in terms of luminescence detection and magnetic resonance imaging. Though this chapter covers a range of different peptides and protein, if focuses specifically on the opportunities afforded by the de novo design of coiled coils, miniature protein scaffolds, and the development on lanthanide-binding sites into these architectures. The requirements for lanthanide coordination and the challenges that need to be addressed when preparing lanthanide peptides with a view to their potential adoption as clinical imaging applications, will be highlighted.

Original languageEnglish
Title of host publicationPeptide, Protein and Enzyme Design
EditorsVincent L. Pecoraro
Place of PublicationCambridge, MA
PublisherAcademic Press Inc.
Chapter24
Pages557-580
Number of pages24
Edition1st
ISBN (Print)978-0-12-805380-5
DOIs
Publication statusPublished - 9 Sept 2016

Publication series

NameMethods in Enzymology
Volume580
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • Coiled coils
  • Coordination chemistry
  • De novo design
  • Gadolinium
  • Imaging
  • Lanthanide
  • Luminescence
  • MRI
  • Peptide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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