De novo designed imaging agents based on lanthanide peptides complexes
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Colleges, School and Institutes
Herein are discussed a selection of lanthanide peptide/protein complexes in view of their potential applications as imaging agents, both in terms of luminescence detection and magnetic resonance imaging. Though this chapter covers a range of different peptides and protein, if focuses specifically on the opportunities afforded by the de novo design of coiled coils, miniature protein scaffolds, and the development on lanthanide-binding sites into these architectures. The requirements for lanthanide coordination and the challenges that need to be addressed when preparing lanthanide peptides with a view to their potential adoption as clinical imaging applications, will be highlighted.
|Title of host publication||Peptide, Protein and Enzyme Design|
|Editors||Vincent L. Pecoraro|
|Publication status||Published - 9 Sep 2016|
|Name||Methods in Enzymology|