De Novo Design of Xeno-Metallo Coiled Coils

Research output: Contribution to journalArticlepeer-review

Standard

De Novo Design of Xeno-Metallo Coiled Coils. / Slope, Louise; Peacock, Anna.

In: Chemistry - An Asian Journal, Vol. 11, No. 5, 04.03.2016, p. 660–666.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{363eed59a0b048278c778a193e3e7606,
title = "De Novo Design of Xeno-Metallo Coiled Coils",
abstract = "Bioinorganic chemists aspire to achieve the same exquisite and highly controlled inorganic chemistry featured in biology. An exciting mimetic approach involves the use of miniature artificial protein scaffolds designed de novo (often based on the coiled coil (CC) scaffold), for reproducing native metal ion sites and their function. Recently, there is increased interest, instead, in the design of xeno-metal sites within CC assemblies. This involves incorporating either non-biological metal ions, cofactors or non-proteinogenic amino acid ligands for metal ion coordination, whilst retaining a minimal CC protein scaffold. Using this approach, one should be able to create functional designs with unique and unusual properties, which combine the advantages of both biology and {\textquoteleft}traditional{\textquoteright} non-biological inorganic chemistry. It is the recent progress with respect to the design of xeno-metallo CCs which will be discussed in this Focus Review.",
author = "Louise Slope and Anna Peacock",
year = "2016",
month = mar,
day = "4",
doi = "10.1002/asia.201501173",
language = "English",
volume = "11",
pages = "660–666",
journal = "Chemistry - An Asian Journal",
issn = "1861-4728",
publisher = "Wiley-VCH Verlag",
number = "5",

}

RIS

TY - JOUR

T1 - De Novo Design of Xeno-Metallo Coiled Coils

AU - Slope, Louise

AU - Peacock, Anna

PY - 2016/3/4

Y1 - 2016/3/4

N2 - Bioinorganic chemists aspire to achieve the same exquisite and highly controlled inorganic chemistry featured in biology. An exciting mimetic approach involves the use of miniature artificial protein scaffolds designed de novo (often based on the coiled coil (CC) scaffold), for reproducing native metal ion sites and their function. Recently, there is increased interest, instead, in the design of xeno-metal sites within CC assemblies. This involves incorporating either non-biological metal ions, cofactors or non-proteinogenic amino acid ligands for metal ion coordination, whilst retaining a minimal CC protein scaffold. Using this approach, one should be able to create functional designs with unique and unusual properties, which combine the advantages of both biology and ‘traditional’ non-biological inorganic chemistry. It is the recent progress with respect to the design of xeno-metallo CCs which will be discussed in this Focus Review.

AB - Bioinorganic chemists aspire to achieve the same exquisite and highly controlled inorganic chemistry featured in biology. An exciting mimetic approach involves the use of miniature artificial protein scaffolds designed de novo (often based on the coiled coil (CC) scaffold), for reproducing native metal ion sites and their function. Recently, there is increased interest, instead, in the design of xeno-metal sites within CC assemblies. This involves incorporating either non-biological metal ions, cofactors or non-proteinogenic amino acid ligands for metal ion coordination, whilst retaining a minimal CC protein scaffold. Using this approach, one should be able to create functional designs with unique and unusual properties, which combine the advantages of both biology and ‘traditional’ non-biological inorganic chemistry. It is the recent progress with respect to the design of xeno-metallo CCs which will be discussed in this Focus Review.

U2 - 10.1002/asia.201501173

DO - 10.1002/asia.201501173

M3 - Article

VL - 11

SP - 660

EP - 666

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

SN - 1861-4728

IS - 5

ER -