De novo design of peptide scaffolds as novel preorganized ligands for metal-ion coordination

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@article{c1d03e8dfb674a59931eb59c53865b45,
title = "De novo design of peptide scaffolds as novel preorganized ligands for metal-ion coordination",
abstract = "This chapter describes how de novo designed peptides can be used as novel preorganized ligands for metal ion coordination. The focus is on the design of peptides which are programmed to spontaneously selfassemble into α-helical coiled coils in aqueous solution, and how metal ion binding sites can be engineered onto and into these structures. In addition to describing the various design principles, some key examples are covered illustrating the success of this approach, including a more detailed example in the case study.",
keywords = "Coiled coil, Coordination chemistry, De novo peptide design, Metal ions, Templated ligands, α-helix",
author = "Gamble, {Aimee J.} and Peacock, {Anna F.A.}",
year = "2014",
month = jan,
day = "1",
doi = "10.1007/978-1-4939-1486-9_11",
language = "English",
volume = "1216",
pages = "211--231",
journal = "Methods in molecular biology",
issn = "1064-3745",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - De novo design of peptide scaffolds as novel preorganized ligands for metal-ion coordination

AU - Gamble, Aimee J.

AU - Peacock, Anna F.A.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - This chapter describes how de novo designed peptides can be used as novel preorganized ligands for metal ion coordination. The focus is on the design of peptides which are programmed to spontaneously selfassemble into α-helical coiled coils in aqueous solution, and how metal ion binding sites can be engineered onto and into these structures. In addition to describing the various design principles, some key examples are covered illustrating the success of this approach, including a more detailed example in the case study.

AB - This chapter describes how de novo designed peptides can be used as novel preorganized ligands for metal ion coordination. The focus is on the design of peptides which are programmed to spontaneously selfassemble into α-helical coiled coils in aqueous solution, and how metal ion binding sites can be engineered onto and into these structures. In addition to describing the various design principles, some key examples are covered illustrating the success of this approach, including a more detailed example in the case study.

KW - Coiled coil

KW - Coordination chemistry

KW - De novo peptide design

KW - Metal ions

KW - Templated ligands

KW - α-helix

UR - http://www.scopus.com/inward/record.url?scp=84921862584&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-1486-9_11

DO - 10.1007/978-1-4939-1486-9_11

M3 - Article

C2 - 25213418

AN - SCOPUS:84921862584

VL - 1216

SP - 211

EP - 231

JO - Methods in molecular biology

JF - Methods in molecular biology

SN - 1064-3745

ER -