De novo design of peptide scaffolds as novel preorganized ligands for metal-ion coordination
Research output: Contribution to journal › Article
Colleges, School and Institutes
This chapter describes how de novo designed peptides can be used as novel preorganized ligands for metal ion coordination. The focus is on the design of peptides which are programmed to spontaneously selfassemble into α-helical coiled coils in aqueous solution, and how metal ion binding sites can be engineered onto and into these structures. In addition to describing the various design principles, some key examples are covered illustrating the success of this approach, including a more detailed example in the case study.
|Number of pages||21|
|Journal||Methods in molecular biology|
|Publication status||Published - 1 Jan 2014|