Abstract
This chapter describes how de novo designed peptides can be used as novel preorganized ligands for metal ion coordination. The focus is on the design of peptides which are programmed to spontaneously selfassemble into α-helical coiled coils in aqueous solution, and how metal ion binding sites can be engineered onto and into these structures. In addition to describing the various design principles, some key examples are covered illustrating the success of this approach, including a more detailed example in the case study.
Original language | English |
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Pages (from-to) | 211-231 |
Number of pages | 21 |
Journal | Methods in molecular biology |
Volume | 1216 |
DOIs | |
Publication status | Published - 20 Aug 2014 |
Keywords
- Coiled coil
- Coordination chemistry
- De novo peptide design
- Metal ions
- Templated ligands
- α-helix
ASJC Scopus subject areas
- Molecular Biology
- Genetics