De novo design of peptide scaffolds as novel preorganized ligands for metal-ion coordination

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Colleges, School and Institutes


This chapter describes how de novo designed peptides can be used as novel preorganized ligands for metal ion coordination. The focus is on the design of peptides which are programmed to spontaneously selfassemble into α-helical coiled coils in aqueous solution, and how metal ion binding sites can be engineered onto and into these structures. In addition to describing the various design principles, some key examples are covered illustrating the success of this approach, including a more detailed example in the case study.


Original languageEnglish
Pages (from-to)211-231
Number of pages21
JournalMethods in molecular biology
Publication statusPublished - 20 Aug 2014


  • Coiled coil, Coordination chemistry, De novo peptide design, Metal ions, Templated ligands, α-helix

ASJC Scopus subject areas