De novo design of Ln(III) coiled coils for imaging applications
Research output: Contribution to journal › Article › peer-review
A new peptide sequence (MB1) has been designed which, in the presence of a trivalent lanthanide ion, has been programmed to self-assemble to form a three stranded metallo-coiled coil, Ln(III)(MB1)3. The binding site has been incorporated into the hydrophobic core using natural amino acids, restricting water access to the lanthanide. The resulting terbium coiled coil displays luminescent properties consistent with a lack of first coordination sphere water molecules. Despite this the gadolinium coiled coil, the first to be reported, displays promising magnetic resonance contrast capabilities.
|Journal||Journal of the American Chemical Society|
|Early online date||9 Jan 2014|
|Publication status||Published - 29 Jan 2014|