De novo design of Ln(III) coiled coils for imaging applications

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A new peptide sequence (MB1) has been designed which, in the presence of a trivalent lanthanide ion, has been programmed to self-assemble to form a three stranded metallo-coiled coil, Ln(III)(MB1)3. The binding site has been incorporated into the hydrophobic core using natural amino acids, restricting water access to the lanthanide. The resulting terbium coiled coil displays luminescent properties consistent with a lack of first coordination sphere water molecules. Despite this the gadolinium coiled coil, the first to be reported, displays promising magnetic resonance contrast capabilities.


Original languageEnglish
Pages (from-to)1166-1169
JournalJournal of the American Chemical Society
Issue number4
Early online date9 Jan 2014
Publication statusPublished - 29 Jan 2014