Daytime variation in hepatitis C virus replication kinetics following liver transplant

Research output: Contribution to journalArticle


  • Xiaodong Zhuang
  • Alvina G Lai
  • Jane A McKeating
  • Ian Rowe
  • Peter Balfe

Colleges, School and Institutes

External organisations

  • Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, OX3 7AZ, UK.
  • Institute for Data Analytics, University of Leeds, Leeds, Yorkshire, UK.


Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. Results: A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. Conclusions: These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation.


Original languageEnglish
JournalWellcome Open Research
Publication statusPublished - 7 Aug 2018


  • HVC, circadian rhythm, liver transplant, allograft, viral rebound, time of day