Daytime variation in hepatitis C virus replication kinetics following liver transplant
Research output: Contribution to journal › Article
Colleges, School and Institutes
- Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, OX3 7AZ, UK.
- Institute for Data Analytics, University of Leeds, Leeds, Yorkshire, UK.
Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. Results: A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. Conclusions: These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation.
|Journal||Wellcome Open Research|
|Publication status||Published - 7 Aug 2018|
- HVC, circadian rhythm, liver transplant, allograft, viral rebound, time of day