Abstract
Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.
Original language | English |
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Pages (from-to) | 2583-7 |
Number of pages | 5 |
Journal | Aids |
Volume | 24 |
Issue number | 16 |
DOIs | |
Publication status | Published - 23 Oct 2010 |