Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

Stephen Taylor, AN Jayasuriya, A Berry, G Gilleran, NE Dufty, L Else, DJ Back, EJ Smit

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.
Original languageEnglish
Pages (from-to)2583-7
Number of pages5
JournalAids
Volume24
Issue number16
DOIs
Publication statusPublished - 23 Oct 2010

Fingerprint

Dive into the research topics of 'Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.'. Together they form a unique fingerprint.

Cite this