Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

Research output: Contribution to journalArticle

Authors

  • AN Jayasuriya
  • A Berry
  • G Gilleran
  • NE Dufty
  • L Else
  • DJ Back
  • EJ Smit

Colleges, School and Institutes

Abstract

Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.

Details

Original languageEnglish
Pages (from-to)2583-7
Number of pages5
JournalAids
Volume24
Issue number16
Publication statusPublished - 23 Oct 2010