Cytomegalovirus is associated with depression and anxiety in older adults

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Cytomegalovirus is associated with depression and anxiety in older adults. / Phillips, Anna; Carroll, Douglas; Khan, N; Moss, Paul.

In: Brain, Behaviour, and Immunity, Vol. 22, No. 1, 01.01.2008, p. 52-55.

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@article{db21de147cf04396a7d631c15d3908fc,
title = "Cytomegalovirus is associated with depression and anxiety in older adults",
abstract = "Infection with cytomegalovirus (CMV), a beta-herpesvirus, is common within the population. Although asymptomatic, infection is associated with increased serum concentrations of cytokines such as TNFalpha and IL-6, which are also related to mood and wellbeing. The present study examined whether infection with CMV was associated with mood in a community-based sample of older adults. Blood samples and scores on the General Health Questionnaire were available for 137 participants. Serum was analysed for the presence of CMV-specific IgG and the antibody titre was used as an indirect measure of viral load. The majority of the participants (66%) were CMV-seropositive and seropositive status was not associated with psychological morbidity. However, within the CMV-positive group, individuals with higher CMV-specific antibody titres were more likely to be depressed, anxious, and suffer more overall psychological morbidity. This association could be mediated by the impact of affect-moderating cytokines secreted through the CMV-specific immune response.",
keywords = "anxiety, ageing, depression, cytomegalovirus",
author = "Anna Phillips and Douglas Carroll and N Khan and Paul Moss",
year = "2008",
month = jan,
day = "1",
doi = "10.1016/j.bbi.2007.06.012",
language = "English",
volume = "22",
pages = "52--55",
journal = "Brain, Behaviour, and Immunity",
issn = "0889-1591",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Cytomegalovirus is associated with depression and anxiety in older adults

AU - Phillips, Anna

AU - Carroll, Douglas

AU - Khan, N

AU - Moss, Paul

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Infection with cytomegalovirus (CMV), a beta-herpesvirus, is common within the population. Although asymptomatic, infection is associated with increased serum concentrations of cytokines such as TNFalpha and IL-6, which are also related to mood and wellbeing. The present study examined whether infection with CMV was associated with mood in a community-based sample of older adults. Blood samples and scores on the General Health Questionnaire were available for 137 participants. Serum was analysed for the presence of CMV-specific IgG and the antibody titre was used as an indirect measure of viral load. The majority of the participants (66%) were CMV-seropositive and seropositive status was not associated with psychological morbidity. However, within the CMV-positive group, individuals with higher CMV-specific antibody titres were more likely to be depressed, anxious, and suffer more overall psychological morbidity. This association could be mediated by the impact of affect-moderating cytokines secreted through the CMV-specific immune response.

AB - Infection with cytomegalovirus (CMV), a beta-herpesvirus, is common within the population. Although asymptomatic, infection is associated with increased serum concentrations of cytokines such as TNFalpha and IL-6, which are also related to mood and wellbeing. The present study examined whether infection with CMV was associated with mood in a community-based sample of older adults. Blood samples and scores on the General Health Questionnaire were available for 137 participants. Serum was analysed for the presence of CMV-specific IgG and the antibody titre was used as an indirect measure of viral load. The majority of the participants (66%) were CMV-seropositive and seropositive status was not associated with psychological morbidity. However, within the CMV-positive group, individuals with higher CMV-specific antibody titres were more likely to be depressed, anxious, and suffer more overall psychological morbidity. This association could be mediated by the impact of affect-moderating cytokines secreted through the CMV-specific immune response.

KW - anxiety

KW - ageing

KW - depression

KW - cytomegalovirus

U2 - 10.1016/j.bbi.2007.06.012

DO - 10.1016/j.bbi.2007.06.012

M3 - Article

C2 - 17703915

VL - 22

SP - 52

EP - 55

JO - Brain, Behaviour, and Immunity

JF - Brain, Behaviour, and Immunity

SN - 0889-1591

IS - 1

ER -