Cytokine-mediated loss of blood dendritic cells during Epstein-Barr virus-associated acute infectious mononucleosis: implication for immune dysregulation
Research output: Contribution to journal › Article
Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. In the current study we demonstrated a significant loss of circulating myeloid and plasmacytoid dendritic cells (DCs) during acute IM, a loss correlated with the severity of clinical symptoms. In vitro exposure of blood DCs to acute IM plasma resulted in loss of plasmacytoid DCs, and further studies with individual cytokines showed that exposure to interleukin 10 could replicate this effect. Our data provide important mechanistic insight into dysregulated immune homeostasis during acute IM.
|Number of pages||5|
|Journal||The Journal of Infectious Diseases|
|Early online date||16 Jun 2015|
|Publication status||Published - 15 Dec 2015|
- immune dysregulation , anti-viral immunity, herpesvirus, acute infection , cytokines, immune regulation, virus, dendritic cells