Cytokine-mediated loss of blood dendritic cells during Epstein-Barr virus-associated acute infectious mononucleosis: implication for immune dysregulation

Research output: Contribution to journalArticlepeer-review


  • Archana Panikkar
  • Corey Smith
  • Nick Tellam
  • Vijayendra Dasari
  • Kristin A Hogquist
  • Michelle Wykes
  • Denis J Moss
  • Henry H Balfour
  • Rajiv Khanna


Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. In the current study we demonstrated a significant loss of circulating myeloid and plasmacytoid dendritic cells (DCs) during acute IM, a loss correlated with the severity of clinical symptoms. In vitro exposure of blood DCs to acute IM plasma resulted in loss of plasmacytoid DCs, and further studies with individual cytokines showed that exposure to interleukin 10 could replicate this effect. Our data provide important mechanistic insight into dysregulated immune homeostasis during acute IM.


Original languageEnglish
Pages (from-to)1957-1961
Number of pages5
JournalThe Journal of Infectious Diseases
Issue number12
Early online date16 Jun 2015
Publication statusPublished - 15 Dec 2015


  • immune dysregulation , anti-viral immunity, herpesvirus, acute infection , cytokines, immune regulation, virus, dendritic cells