Cutting edge: failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis

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Cutting edge : failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis. / Drummond, Rebecca A.; Wallace, Carol; Reid, Delyth M.; Way, Sing Sing; Kaplan, Daniel H.; Brown, Gordon D.

In: Journal of Immunology, Vol. 193, No. 11, 01.01.2014, p. 5381-5385.

Research output: Contribution to journalArticlepeer-review

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Drummond, Rebecca A. ; Wallace, Carol ; Reid, Delyth M. ; Way, Sing Sing ; Kaplan, Daniel H. ; Brown, Gordon D. / Cutting edge : failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis. In: Journal of Immunology. 2014 ; Vol. 193, No. 11. pp. 5381-5385.

Bibtex

@article{ae713786316e4124b67652cb1dac4634,
title = "Cutting edge: failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis",
abstract = "Candida albicans is the leading cause of systemic candidiasis, a fungal disease associated with high mortality and poor treatment options. The kidney is the target organ during infection and whose control is largely dependent on innate immunity, because lymphocytes appear redundant for protection. In this article, we show that this apparent redundancy stems from a failure of Ag-specific CD4+ T cells to migrate into infected kidneys. In contrast, Ag-specific CD8+ T cells are recruited normally. Using Ag-loaded immunoliposomes to artificially reverse this defective migration, we show that recruited Ag-specific CD4+ T cells polarize toward a Th17 phenotype in the kidney and are protective during fungal infection. Therefore, our data explain the redundancy of CD4+ T cells for defense against systemic infection with C. albicans and have important implications for our understanding of antifungal immunity and the control of renal infections.",
author = "Drummond, {Rebecca A.} and Carol Wallace and Reid, {Delyth M.} and Way, {Sing Sing} and Kaplan, {Daniel H.} and Brown, {Gordon D.}",
year = "2014",
month = jan,
day = "1",
doi = "10.4049/jimmunol.1401675",
language = "English",
volume = "193",
pages = "5381--5385",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "11",

}

RIS

TY - JOUR

T1 - Cutting edge

T2 - failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis

AU - Drummond, Rebecca A.

AU - Wallace, Carol

AU - Reid, Delyth M.

AU - Way, Sing Sing

AU - Kaplan, Daniel H.

AU - Brown, Gordon D.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Candida albicans is the leading cause of systemic candidiasis, a fungal disease associated with high mortality and poor treatment options. The kidney is the target organ during infection and whose control is largely dependent on innate immunity, because lymphocytes appear redundant for protection. In this article, we show that this apparent redundancy stems from a failure of Ag-specific CD4+ T cells to migrate into infected kidneys. In contrast, Ag-specific CD8+ T cells are recruited normally. Using Ag-loaded immunoliposomes to artificially reverse this defective migration, we show that recruited Ag-specific CD4+ T cells polarize toward a Th17 phenotype in the kidney and are protective during fungal infection. Therefore, our data explain the redundancy of CD4+ T cells for defense against systemic infection with C. albicans and have important implications for our understanding of antifungal immunity and the control of renal infections.

AB - Candida albicans is the leading cause of systemic candidiasis, a fungal disease associated with high mortality and poor treatment options. The kidney is the target organ during infection and whose control is largely dependent on innate immunity, because lymphocytes appear redundant for protection. In this article, we show that this apparent redundancy stems from a failure of Ag-specific CD4+ T cells to migrate into infected kidneys. In contrast, Ag-specific CD8+ T cells are recruited normally. Using Ag-loaded immunoliposomes to artificially reverse this defective migration, we show that recruited Ag-specific CD4+ T cells polarize toward a Th17 phenotype in the kidney and are protective during fungal infection. Therefore, our data explain the redundancy of CD4+ T cells for defense against systemic infection with C. albicans and have important implications for our understanding of antifungal immunity and the control of renal infections.

UR - http://www.scopus.com/inward/record.url?scp=84912521775&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.1401675

DO - 10.4049/jimmunol.1401675

M3 - Article

C2 - 25344471

AN - SCOPUS:84912521775

VL - 193

SP - 5381

EP - 5385

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 11

ER -