Current insights into the aetiology, pathobiology, and management of local disease recurrence in squamous cell carcinoma of the vulva

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • Department of Obstetrics and Gynaecology, Birmingham City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Abstract

Squamous cell carcinoma of the vulva is predominantly a disease of the elderly, where the mainstay of treatment is radical surgery. Local vulval recurrence (LVR) is a significant problem for these patients, and the rates of recurrence have not improved over the last three decades. Disappointingly, we still lack an understanding of how LVRs develop, and the best approach to prevent and manage the condition. This review discusses recent insights into the key prognostic factors that influence the risk of recurrence, focusing on the role of tumour-adjacent non-neoplastic epithelial disorders, which are thought to play a causative role.

TWEETABLE ABSTRACT: A review that discusses the key prognostic factors that influence local recurrence in vulval cancer.

Details

Original languageEnglish
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Early online date12 Jan 2017
Publication statusPublished - 9 Mar 2017

Keywords

  • Journal Article, Review, Lichen sclerosus , local disease recurrence , squamous cell carcinoma , vulva , vulvar intraepithelial neoplasia