Abstract
Squamous cell carcinoma of the vulva is predominantly a disease of the elderly, where the mainstay of treatment is radical surgery. Local vulval recurrence (LVR) is a significant problem for these patients, and the rates of recurrence have not improved over the last three decades. Disappointingly, we still lack an understanding of how LVRs develop, and the best approach to prevent and manage the condition. This review discusses recent insights into the key prognostic factors that influence the risk of recurrence, focusing on the role of tumour-adjacent non-neoplastic epithelial disorders, which are thought to play a causative role.
TWEETABLE ABSTRACT: A review that discusses the key prognostic factors that influence local recurrence in vulval cancer.
| Original language | English |
|---|---|
| Journal | BJOG: An International Journal of Obstetrics & Gynaecology |
| Early online date | 12 Jan 2017 |
| DOIs | |
| Publication status | Published - 9 Mar 2017 |
Keywords
- Journal Article
- Review
- Lichen sclerosus
- local disease recurrence
- squamous cell carcinoma
- vulva
- vulvar intraepithelial neoplasia
Access to Document
- Yap_et_al_Current_insights_into_the_aetiology_BJOG_2017
This is the peer reviewed version of the following article: Yap JKW, O'Neill D, Nagenthiran S, Dawson CW, Luesley DM. Current insights into the aetiology, pathobiology, and management of local disease recurrence in squamous cell carcinoma of the vulva. BJOG 2017; DOI: 10.1111/1471-0528.14560, which has been published in final form at 10.1111/1471-0528.14560. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.