Cu(OTf)2-catalysed Ritter reaction: Efficient synthesis of amides from nitriles and halohydrocarbons in water

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An efficient and green protocol for the synthesis of amides through the Ritter reaction of nitriles and halohydrocarbons was developed. Cu(OTf) economically efficiently catalysed the Ritter reaction in water. A range of halohydrocarbons (benzyl, tert-butyl, sec-alkyl and primary alkyl halohydrocarbons) were coupled with nitriles, providing the corresponding amides. This journal is


Original languageEnglish
Pages (from-to)6161-6163
Number of pages3
JournalRSC Advances
Issue number15
Publication statusPublished - 7 Aug 2012