TY - JOUR
T1 - CTLA4 gene polymorphism and autoimmunity
AU - Gough, Stephen
AU - Walker, Lucy
AU - Sansom, David
PY - 2005/4/1
Y1 - 2005/4/1
N2 - CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4) are two receptors that have critical but opposing functions in T-cell stimulation. CD28 promotes a number of T-cell activities, whereas in contrast CTLA4 is an essential inhibitor of T-cell responses. Because of its inhibitory role, CTLA4 is a strong candidate susceptibility gene in autoimmunity and several studies suggest disease-associated polymorphisms. In this review, we discuss recent progress in relating CTLA4 polymorphisms to disease susceptibility and consider the putative mechanisms by which CTLA4 may act to inhibit autoimmunity.
AB - CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4) are two receptors that have critical but opposing functions in T-cell stimulation. CD28 promotes a number of T-cell activities, whereas in contrast CTLA4 is an essential inhibitor of T-cell responses. Because of its inhibitory role, CTLA4 is a strong candidate susceptibility gene in autoimmunity and several studies suggest disease-associated polymorphisms. In this review, we discuss recent progress in relating CTLA4 polymorphisms to disease susceptibility and consider the putative mechanisms by which CTLA4 may act to inhibit autoimmunity.
UR - http://www.scopus.com/inward/record.url?scp=16244369437&partnerID=8YFLogxK
U2 - 10.1111/j.0105-2896.2005.00249.x
DO - 10.1111/j.0105-2896.2005.00249.x
M3 - Review article
C2 - 15790353
SN - 1600-065X
SN - 1600-065X
SN - 1600-065X
SN - 1600-065X
SN - 1600-065X
VL - 204
SP - 102
EP - 115
JO - Immunological Reviews
JF - Immunological Reviews
ER -