COVID-19 in children with haematological malignancies

Research output: Contribution to journalArticle

Authors

External organisations

  • Birmingham Children’s Hospital NHS Foundation Trust,
  • University of Leeds
  • Children's Cancer and Leukaemia Group
  • University of Oxford
  • National Cancer Registration and Analysis Service (NCRAS)
  • University of Nottingham
  • University of Manchester
  • Public Health England
  • Leeds Children's Hospital
  • University of York

Abstract

Background 

Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.


Methods 

We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.


Results 

Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.


Interpretation 

Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.


Data availability statement

Data are available on reasonable request. The database contains de-identified participant data which are anonymised at source prior to upload. Reasonable requests for data sharing will be considered.

Details

Original languageEnglish
JournalArchives of Disease in Childhood
Early online date22 Jul 2021
Publication statusE-pub ahead of print - 22 Jul 2021

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