Cortisol and cardiovascular reactions to mental stress and antibody status following hepatitis B vaccination: A preliminary study

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@article{7583705a2555422bbb7c13b261ff77e7,
title = "Cortisol and cardiovascular reactions to mental stress and antibody status following hepatitis B vaccination: A preliminary study",
abstract = "This study examined possible neuroendocrine mechanisms underlying the association between stress and antibody response to vaccination. Hepatitis B antibody titers were obtained, and salivary cortisol and cardiovascular activity measured during baseline, mental arithmetic, and recovery in 30 undergraduates. It was hypothesised that higher reactivity would be associated with poorer antibody status. Compared to individuals with high antibody titers, those with low titers had significantly lower cortisol levels throughout, exhibited a significantly attenuated end-of-task reduction in cortisol relative to resting baseline, and had larger cardiac output and inotropic reactions, but smaller increases in total peripheral resistance, to mental arithmetic. In sum, variations in indices of both hypothalamic pituitary adrenocortical axis and sympathetic nervous system activity were associated with individual differences in immune response to vaccination.",
keywords = "sympathetic nervous system, mental stress, hepatitis B vaccination, cortisol, cardiovascular activity, hypothalamic pituitary adrenocortical axis",
author = "Victoria Burns and Christopher Ring and Mark Drayson and Douglas Carroll",
year = "2002",
month = may,
day = "1",
doi = "10.1017/S0048577201393022",
language = "English",
volume = "39",
pages = "361--368",
journal = "Psychophysiology",
issn = "0048-5772",
publisher = "Wiley Online Library",
number = "3",

}

RIS

TY - JOUR

T1 - Cortisol and cardiovascular reactions to mental stress and antibody status following hepatitis B vaccination: A preliminary study

AU - Burns, Victoria

AU - Ring, Christopher

AU - Drayson, Mark

AU - Carroll, Douglas

PY - 2002/5/1

Y1 - 2002/5/1

N2 - This study examined possible neuroendocrine mechanisms underlying the association between stress and antibody response to vaccination. Hepatitis B antibody titers were obtained, and salivary cortisol and cardiovascular activity measured during baseline, mental arithmetic, and recovery in 30 undergraduates. It was hypothesised that higher reactivity would be associated with poorer antibody status. Compared to individuals with high antibody titers, those with low titers had significantly lower cortisol levels throughout, exhibited a significantly attenuated end-of-task reduction in cortisol relative to resting baseline, and had larger cardiac output and inotropic reactions, but smaller increases in total peripheral resistance, to mental arithmetic. In sum, variations in indices of both hypothalamic pituitary adrenocortical axis and sympathetic nervous system activity were associated with individual differences in immune response to vaccination.

AB - This study examined possible neuroendocrine mechanisms underlying the association between stress and antibody response to vaccination. Hepatitis B antibody titers were obtained, and salivary cortisol and cardiovascular activity measured during baseline, mental arithmetic, and recovery in 30 undergraduates. It was hypothesised that higher reactivity would be associated with poorer antibody status. Compared to individuals with high antibody titers, those with low titers had significantly lower cortisol levels throughout, exhibited a significantly attenuated end-of-task reduction in cortisol relative to resting baseline, and had larger cardiac output and inotropic reactions, but smaller increases in total peripheral resistance, to mental arithmetic. In sum, variations in indices of both hypothalamic pituitary adrenocortical axis and sympathetic nervous system activity were associated with individual differences in immune response to vaccination.

KW - sympathetic nervous system

KW - mental stress

KW - hepatitis B vaccination

KW - cortisol

KW - cardiovascular activity

KW - hypothalamic pituitary adrenocortical axis

UR - http://www.scopus.com/inward/record.url?scp=0036245502&partnerID=8YFLogxK

U2 - 10.1017/S0048577201393022

DO - 10.1017/S0048577201393022

M3 - Article

C2 - 12212655

VL - 39

SP - 361

EP - 368

JO - Psychophysiology

JF - Psychophysiology

SN - 0048-5772

IS - 3

ER -