Cortical thickness, surface area, and gyrification abnormalities in children exposed to maltreatment : neural markers of vulnerability?

Research output: Contribution to journalArticlepeer-review

Standard

Cortical thickness, surface area, and gyrification abnormalities in children exposed to maltreatment : neural markers of vulnerability? / Kelly, Philip A.; Viding, Essi; Wallace, Gregory L.; Schaer, Marie; De Brito, Stephane A.; Robustelli, Briana; Mccrory, Eamon J.

In: Biological Psychiatry, Vol. 74, No. 11, 01.12.2013, p. 845-852.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Kelly, Philip A. ; Viding, Essi ; Wallace, Gregory L. ; Schaer, Marie ; De Brito, Stephane A. ; Robustelli, Briana ; Mccrory, Eamon J. / Cortical thickness, surface area, and gyrification abnormalities in children exposed to maltreatment : neural markers of vulnerability?. In: Biological Psychiatry. 2013 ; Vol. 74, No. 11. pp. 845-852.

Bibtex

@article{67e19f82b14344f7937b84ffb7a4167e,
title = "Cortical thickness, surface area, and gyrification abnormalities in children exposed to maltreatment : neural markers of vulnerability?",
abstract = "BackgroundChildhood maltreatment has been shown to significantly elevate the risk of psychiatric disorder. Previous neuroimaging studies of children exposed to maltreatment have reported atypical neural structure in several regions, including the prefrontal cortex and temporal lobes. These studies have exclusively investigated volumetric differences rather than focusing on genetically and developmentally distinct indices of brain structure.MethodsHere we used surface-based methods to examine cortical thickness, surface area, and local gyrification in a community sample of children with documented experiences of abuse (n = 22) and a group of carefully matched nonmaltreated peers (n = 21).ResultsReduced cortical thickness in the maltreated compared with the nonmaltreated group was observed in an extended cluster that incorporated the anterior cingulate, superior frontal gyrus, and orbitofrontal cortex. In addition, reduced cortical surface area was observed within the parcellated regions of the left middle temporal area and lingual gyrus. Local gyrification deficits within the maltreated group were located within two clusters, the lingual gyrus and the insula extending into pars opercularis.ConclusionsThis is the first time structural abnormalities in the anterior cingulate and lingual gyrus have been detected in children exposed to maltreatment. Surface-based methods seem to capture subtle, previously undetected, morphological abnormalities associated with maltreatment. We suggest that these approaches detect developmental precursors of brain volume differences seen in adults with histories of abuse. Because the reported regions are implicated in several clinical disorders, they might constitute biological markers of vulnerability, linking exposure to early adversity and psychiatric risk.",
keywords = "Child abuse, cortical thickness, local gyrification, maltreatment, psychopathology, surface area",
author = "Kelly, {Philip A.} and Essi Viding and Wallace, {Gregory L.} and Marie Schaer and {De Brito}, {Stephane A.} and Briana Robustelli and Mccrory, {Eamon J.}",
year = "2013",
month = dec,
day = "1",
doi = "10.1016/j.biopsych.2013.06.020",
language = "English",
volume = "74",
pages = "845--852",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Cortical thickness, surface area, and gyrification abnormalities in children exposed to maltreatment : neural markers of vulnerability?

AU - Kelly, Philip A.

AU - Viding, Essi

AU - Wallace, Gregory L.

AU - Schaer, Marie

AU - De Brito, Stephane A.

AU - Robustelli, Briana

AU - Mccrory, Eamon J.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - BackgroundChildhood maltreatment has been shown to significantly elevate the risk of psychiatric disorder. Previous neuroimaging studies of children exposed to maltreatment have reported atypical neural structure in several regions, including the prefrontal cortex and temporal lobes. These studies have exclusively investigated volumetric differences rather than focusing on genetically and developmentally distinct indices of brain structure.MethodsHere we used surface-based methods to examine cortical thickness, surface area, and local gyrification in a community sample of children with documented experiences of abuse (n = 22) and a group of carefully matched nonmaltreated peers (n = 21).ResultsReduced cortical thickness in the maltreated compared with the nonmaltreated group was observed in an extended cluster that incorporated the anterior cingulate, superior frontal gyrus, and orbitofrontal cortex. In addition, reduced cortical surface area was observed within the parcellated regions of the left middle temporal area and lingual gyrus. Local gyrification deficits within the maltreated group were located within two clusters, the lingual gyrus and the insula extending into pars opercularis.ConclusionsThis is the first time structural abnormalities in the anterior cingulate and lingual gyrus have been detected in children exposed to maltreatment. Surface-based methods seem to capture subtle, previously undetected, morphological abnormalities associated with maltreatment. We suggest that these approaches detect developmental precursors of brain volume differences seen in adults with histories of abuse. Because the reported regions are implicated in several clinical disorders, they might constitute biological markers of vulnerability, linking exposure to early adversity and psychiatric risk.

AB - BackgroundChildhood maltreatment has been shown to significantly elevate the risk of psychiatric disorder. Previous neuroimaging studies of children exposed to maltreatment have reported atypical neural structure in several regions, including the prefrontal cortex and temporal lobes. These studies have exclusively investigated volumetric differences rather than focusing on genetically and developmentally distinct indices of brain structure.MethodsHere we used surface-based methods to examine cortical thickness, surface area, and local gyrification in a community sample of children with documented experiences of abuse (n = 22) and a group of carefully matched nonmaltreated peers (n = 21).ResultsReduced cortical thickness in the maltreated compared with the nonmaltreated group was observed in an extended cluster that incorporated the anterior cingulate, superior frontal gyrus, and orbitofrontal cortex. In addition, reduced cortical surface area was observed within the parcellated regions of the left middle temporal area and lingual gyrus. Local gyrification deficits within the maltreated group were located within two clusters, the lingual gyrus and the insula extending into pars opercularis.ConclusionsThis is the first time structural abnormalities in the anterior cingulate and lingual gyrus have been detected in children exposed to maltreatment. Surface-based methods seem to capture subtle, previously undetected, morphological abnormalities associated with maltreatment. We suggest that these approaches detect developmental precursors of brain volume differences seen in adults with histories of abuse. Because the reported regions are implicated in several clinical disorders, they might constitute biological markers of vulnerability, linking exposure to early adversity and psychiatric risk.

KW - Child abuse

KW - cortical thickness

KW - local gyrification

KW - maltreatment

KW - psychopathology

KW - surface area

U2 - 10.1016/j.biopsych.2013.06.020

DO - 10.1016/j.biopsych.2013.06.020

M3 - Article

C2 - 23954109

VL - 74

SP - 845

EP - 852

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 11

ER -