Corpus callosum abnormalities in Tourette syndrome: a MRI-DTI study of monozygotic twins

Andrea Cavanna; A Stecco; Hugh Rickards; S Servo; E Terazzi; B Peterson; MM Robertson; A Carriero; F Monaco

doi:10.1136/jnnp.2009.173666

Corpus callosum abnormalities in Tourette syndrome: a MRI-DTI study of monozygotic twins

Andrea Cavanna, A Stecco, Hugh Rickards, S Servo, E Terazzi, B Peterson, MM Robertson, A Carriero, F Monaco

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Abstract

BACKGROUND: Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by the presence of multiple motor and phonic tics. Recent brain imaging investigations with diffusion tensor imaging (DTI) techniques found reduced measures of connectivity in the corpus callosum of children with TS compared with healthy controls, thus raising the hypothesis that the reduced interhemispherical connectivity in TS reflects neural plasticity processes. METHODS: We assessed corpus callosum white-matter connectivity with fractional anisotropy (FA) index from magnetic resonance-DTI in two monozygotic twins (male sex; age 20) discordant for the diagnosis of TS. RESULTS: Both conventional morphological magnetic resonance images and fibre-tracking reconstruction failed to show any difference between the two twins. On the other hand, mean corpus callosum FA values were significantly lower in the affected twin than in the unaffected twin (p

Original language	English
Pages (from-to)	533-535
Number of pages	3
Journal	Journal of Neurology Neurosurgery and Psychiatry
Volume	81
Issue number	5
DOIs	https://doi.org/10.1136/jnnp.2009.173666
Publication status	Published - 1 Jan 2009

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title = "Corpus callosum abnormalities in Tourette syndrome: a MRI-DTI study of monozygotic twins",

abstract = "BACKGROUND: Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by the presence of multiple motor and phonic tics. Recent brain imaging investigations with diffusion tensor imaging (DTI) techniques found reduced measures of connectivity in the corpus callosum of children with TS compared with healthy controls, thus raising the hypothesis that the reduced interhemispherical connectivity in TS reflects neural plasticity processes. METHODS: We assessed corpus callosum white-matter connectivity with fractional anisotropy (FA) index from magnetic resonance-DTI in two monozygotic twins (male sex; age 20) discordant for the diagnosis of TS. RESULTS: Both conventional morphological magnetic resonance images and fibre-tracking reconstruction failed to show any difference between the two twins. On the other hand, mean corpus callosum FA values were significantly lower in the affected twin than in the unaffected twin (p",

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T1 - Corpus callosum abnormalities in Tourette syndrome: a MRI-DTI study of monozygotic twins

AU - Cavanna, Andrea

AU - Stecco, A

AU - Rickards, Hugh

AU - Servo, S

AU - Terazzi, E

AU - Peterson, B

AU - Robertson, MM

AU - Carriero, A

AU - Monaco, F

PY - 2009/1/1

Y1 - 2009/1/1

N2 - BACKGROUND: Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by the presence of multiple motor and phonic tics. Recent brain imaging investigations with diffusion tensor imaging (DTI) techniques found reduced measures of connectivity in the corpus callosum of children with TS compared with healthy controls, thus raising the hypothesis that the reduced interhemispherical connectivity in TS reflects neural plasticity processes. METHODS: We assessed corpus callosum white-matter connectivity with fractional anisotropy (FA) index from magnetic resonance-DTI in two monozygotic twins (male sex; age 20) discordant for the diagnosis of TS. RESULTS: Both conventional morphological magnetic resonance images and fibre-tracking reconstruction failed to show any difference between the two twins. On the other hand, mean corpus callosum FA values were significantly lower in the affected twin than in the unaffected twin (p

AB - BACKGROUND: Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by the presence of multiple motor and phonic tics. Recent brain imaging investigations with diffusion tensor imaging (DTI) techniques found reduced measures of connectivity in the corpus callosum of children with TS compared with healthy controls, thus raising the hypothesis that the reduced interhemispherical connectivity in TS reflects neural plasticity processes. METHODS: We assessed corpus callosum white-matter connectivity with fractional anisotropy (FA) index from magnetic resonance-DTI in two monozygotic twins (male sex; age 20) discordant for the diagnosis of TS. RESULTS: Both conventional morphological magnetic resonance images and fibre-tracking reconstruction failed to show any difference between the two twins. On the other hand, mean corpus callosum FA values were significantly lower in the affected twin than in the unaffected twin (p

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DO - 10.1136/jnnp.2009.173666

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Corpus callosum abnormalities in Tourette syndrome: a MRI-DTI study of monozygotic twins

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