Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol-ene radical reactions

Research output: Contribution to journalArticlepeer-review

Standard

Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol-ene radical reactions. / Sun, Liang; Pitto-Barry, Anais; Thomas, Anthony W.; Inam, Maria; Doncom, Kay; Dove, Andrew P.; O'Reilly, Rachel K.

In: Polymer Chemistry, Vol. 7, 25.02.2016, p. 2337-2341.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{ee96a670f9f34d9c9fe2d86f4cafa5fc,
title = "Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol-ene radical reactions",
abstract = "Sequential ring-opening and reversible addition–fragmentation chain transfer (RAFT) polymerization was used to form a triblock copolymer of tetrahydropyran acrylate (THPA), 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) and L-lactide. Concurrent deprotection of the THPA block and crystallization-driven self-assembly (CDSA) was undertaken and allowed for the formation of cylindrical micelles bearing allyl handles in a short outer core segment. These handles were further functionalized by different thiols using photo-initiated thiol–ene radical reactions to demonstrate that the incorporation of an amorphous PMAC block within the core does not disrupt CDSA and can be used to load the cylindrical nanoparticles with cargo.",
author = "Liang Sun and Anais Pitto-Barry and Thomas, {Anthony W.} and Maria Inam and Kay Doncom and Dove, {Andrew P.} and O'Reilly, {Rachel K.}",
year = "2016",
month = feb,
day = "25",
doi = "10.1039/c5py01970b",
language = "English",
volume = "7",
pages = "2337--2341",
journal = "Polymer Chemistry",
issn = "1759-9954",
publisher = "Royal Society of Chemistry",

}

RIS

TY - JOUR

T1 - Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol-ene radical reactions

AU - Sun, Liang

AU - Pitto-Barry, Anais

AU - Thomas, Anthony W.

AU - Inam, Maria

AU - Doncom, Kay

AU - Dove, Andrew P.

AU - O'Reilly, Rachel K.

PY - 2016/2/25

Y1 - 2016/2/25

N2 - Sequential ring-opening and reversible addition–fragmentation chain transfer (RAFT) polymerization was used to form a triblock copolymer of tetrahydropyran acrylate (THPA), 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) and L-lactide. Concurrent deprotection of the THPA block and crystallization-driven self-assembly (CDSA) was undertaken and allowed for the formation of cylindrical micelles bearing allyl handles in a short outer core segment. These handles were further functionalized by different thiols using photo-initiated thiol–ene radical reactions to demonstrate that the incorporation of an amorphous PMAC block within the core does not disrupt CDSA and can be used to load the cylindrical nanoparticles with cargo.

AB - Sequential ring-opening and reversible addition–fragmentation chain transfer (RAFT) polymerization was used to form a triblock copolymer of tetrahydropyran acrylate (THPA), 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) and L-lactide. Concurrent deprotection of the THPA block and crystallization-driven self-assembly (CDSA) was undertaken and allowed for the formation of cylindrical micelles bearing allyl handles in a short outer core segment. These handles were further functionalized by different thiols using photo-initiated thiol–ene radical reactions to demonstrate that the incorporation of an amorphous PMAC block within the core does not disrupt CDSA and can be used to load the cylindrical nanoparticles with cargo.

U2 - 10.1039/c5py01970b

DO - 10.1039/c5py01970b

M3 - Article

VL - 7

SP - 2337

EP - 2341

JO - Polymer Chemistry

JF - Polymer Chemistry

SN - 1759-9954

ER -