Cord blood unit dominance analysis and effect of winning unit on outcomes after double-unit umbilical cord blood transplantation in adults with acute leukemia: a retrospective study on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobilogy Working Party, and Acute Leukemia Working Party of the European group for blood and marrow transplantation

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Cord blood unit dominance analysis and effect of winning unit on outcomes after double-unit umbilical cord blood transplantation in adults with acute leukemia : a retrospective study on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobilogy Working Party, and Acute Leukemia Working Party of the European group for blood and marrow transplantation. / Tozatto-maio, Karina; Giannotti, Federica; Labopin, Myriam; Ruggeri, Annalisa; Volt, Fernanda; Paviglianiti, Annalisa; Kenzey, Chantal; Hayashi, Hiromi; Cornelissen, Jan; Michallet, Mauricette; Karakasis, Dimitrios; Deconinck, Eric; Rohrlich, Pierre-simon; De La Tour, Regis Peffault; Blaise, Didier; Petersen, Eefke; D'aveni, Maud; Sengeloev, Henrik; Lamy, Thierry; Russell, Nigel H.; Forcade, Edouard; Craddock, Charles F.; Nagler, Arnon; Gluckman, Eliane; Rocha, Vanderson.

In: Biology of Blood and Marrow Transplantation , 01.03.2018.

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Tozatto-maio, K, Giannotti, F, Labopin, M, Ruggeri, A, Volt, F, Paviglianiti, A, Kenzey, C, Hayashi, H, Cornelissen, J, Michallet, M, Karakasis, D, Deconinck, E, Rohrlich, P, De La Tour, RP, Blaise, D, Petersen, E, D'aveni, M, Sengeloev, H, Lamy, T, Russell, NH, Forcade, E, Craddock, CF, Nagler, A, Gluckman, E & Rocha, V 2018, 'Cord blood unit dominance analysis and effect of winning unit on outcomes after double-unit umbilical cord blood transplantation in adults with acute leukemia: a retrospective study on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobilogy Working Party, and Acute Leukemia Working Party of the European group for blood and marrow transplantation', Biology of Blood and Marrow Transplantation . https://doi.org/10.1016/j.bbmt.2018.02.014

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Tozatto-maio, Karina ; Giannotti, Federica ; Labopin, Myriam ; Ruggeri, Annalisa ; Volt, Fernanda ; Paviglianiti, Annalisa ; Kenzey, Chantal ; Hayashi, Hiromi ; Cornelissen, Jan ; Michallet, Mauricette ; Karakasis, Dimitrios ; Deconinck, Eric ; Rohrlich, Pierre-simon ; De La Tour, Regis Peffault ; Blaise, Didier ; Petersen, Eefke ; D'aveni, Maud ; Sengeloev, Henrik ; Lamy, Thierry ; Russell, Nigel H. ; Forcade, Edouard ; Craddock, Charles F. ; Nagler, Arnon ; Gluckman, Eliane ; Rocha, Vanderson. / Cord blood unit dominance analysis and effect of winning unit on outcomes after double-unit umbilical cord blood transplantation in adults with acute leukemia : a retrospective study on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobilogy Working Party, and Acute Leukemia Working Party of the European group for blood and marrow transplantation. In: Biology of Blood and Marrow Transplantation . 2018.

Bibtex

@article{4bdcc77d9ae14c1cbd39ee2b6558b220,
title = "Cord blood unit dominance analysis and effect of winning unit on outcomes after double-unit umbilical cord blood transplantation in adults with acute leukemia: a retrospective study on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobilogy Working Party, and Acute Leukemia Working Party of the European group for blood and marrow transplantation",
abstract = "Usually, after double umbilical cord blood transplantation (DUCBT), only 1 of the transplanted units persists in the long term. The characteristics of the winning cord blood unit (W-CBU) that determine unit dominance and how they influence the outcomes of DUCBT remain unclear. We retrospectively analyzed 347 patients with acute leukemia transplanted with a DUCBT (694 CBU) from 2005 to 2013 who had documented neutrophil engraftment and a W-CBU identified by chimerism analysis, to identify unit characteristics impacting on dominance. Median age at DUCBT was 40 years and median follow-up was 35 months. Among W-CBUs, 41% were ≥5/6 HLA matched to the recipient and 59% were ≤4/6. Multivariate analysis indicated that ≤4/6 HLA-matched W-CBUs led to lower leukemia-free survival (44% versus 56%; hazard ratio [HR], 1.5; P = .032) and overall survival (49% versus 62%; HR, 1.5; P = .028), increased nonrelapse mortality (26% versus 18%; HR, 1.9; P = .027), and acute graft-versus-host disease (46% versus 35%; HR, 1.7; P = .013). We were unable to predict unit dominance, but we demonstrated that outcomes were strongly influenced by the degree of HLA mismatch between W-CBU and recipient. Therefore, selection of both units with the lower number of HLA mismatches with the recipient is indicated.",
keywords = "Double cord blood transplantation, Winning cord blood unit, Unit dominance, Acute leukemia, HLA",
author = "Karina Tozatto-maio and Federica Giannotti and Myriam Labopin and Annalisa Ruggeri and Fernanda Volt and Annalisa Paviglianiti and Chantal Kenzey and Hiromi Hayashi and Jan Cornelissen and Mauricette Michallet and Dimitrios Karakasis and Eric Deconinck and Pierre-simon Rohrlich and {De La Tour}, {Regis Peffault} and Didier Blaise and Eefke Petersen and Maud D'aveni and Henrik Sengeloev and Thierry Lamy and Russell, {Nigel H.} and Edouard Forcade and Craddock, {Charles F.} and Arnon Nagler and Eliane Gluckman and Vanderson Rocha",
year = "2018",
month = mar
day = "1",
doi = "10.1016/j.bbmt.2018.02.014",
language = "English",
journal = "Biology of Blood and Marrow Transplantation ",
issn = "1083-8791",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Cord blood unit dominance analysis and effect of winning unit on outcomes after double-unit umbilical cord blood transplantation in adults with acute leukemia

T2 - a retrospective study on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobilogy Working Party, and Acute Leukemia Working Party of the European group for blood and marrow transplantation

AU - Tozatto-maio, Karina

AU - Giannotti, Federica

AU - Labopin, Myriam

AU - Ruggeri, Annalisa

AU - Volt, Fernanda

AU - Paviglianiti, Annalisa

AU - Kenzey, Chantal

AU - Hayashi, Hiromi

AU - Cornelissen, Jan

AU - Michallet, Mauricette

AU - Karakasis, Dimitrios

AU - Deconinck, Eric

AU - Rohrlich, Pierre-simon

AU - De La Tour, Regis Peffault

AU - Blaise, Didier

AU - Petersen, Eefke

AU - D'aveni, Maud

AU - Sengeloev, Henrik

AU - Lamy, Thierry

AU - Russell, Nigel H.

AU - Forcade, Edouard

AU - Craddock, Charles F.

AU - Nagler, Arnon

AU - Gluckman, Eliane

AU - Rocha, Vanderson

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Usually, after double umbilical cord blood transplantation (DUCBT), only 1 of the transplanted units persists in the long term. The characteristics of the winning cord blood unit (W-CBU) that determine unit dominance and how they influence the outcomes of DUCBT remain unclear. We retrospectively analyzed 347 patients with acute leukemia transplanted with a DUCBT (694 CBU) from 2005 to 2013 who had documented neutrophil engraftment and a W-CBU identified by chimerism analysis, to identify unit characteristics impacting on dominance. Median age at DUCBT was 40 years and median follow-up was 35 months. Among W-CBUs, 41% were ≥5/6 HLA matched to the recipient and 59% were ≤4/6. Multivariate analysis indicated that ≤4/6 HLA-matched W-CBUs led to lower leukemia-free survival (44% versus 56%; hazard ratio [HR], 1.5; P = .032) and overall survival (49% versus 62%; HR, 1.5; P = .028), increased nonrelapse mortality (26% versus 18%; HR, 1.9; P = .027), and acute graft-versus-host disease (46% versus 35%; HR, 1.7; P = .013). We were unable to predict unit dominance, but we demonstrated that outcomes were strongly influenced by the degree of HLA mismatch between W-CBU and recipient. Therefore, selection of both units with the lower number of HLA mismatches with the recipient is indicated.

AB - Usually, after double umbilical cord blood transplantation (DUCBT), only 1 of the transplanted units persists in the long term. The characteristics of the winning cord blood unit (W-CBU) that determine unit dominance and how they influence the outcomes of DUCBT remain unclear. We retrospectively analyzed 347 patients with acute leukemia transplanted with a DUCBT (694 CBU) from 2005 to 2013 who had documented neutrophil engraftment and a W-CBU identified by chimerism analysis, to identify unit characteristics impacting on dominance. Median age at DUCBT was 40 years and median follow-up was 35 months. Among W-CBUs, 41% were ≥5/6 HLA matched to the recipient and 59% were ≤4/6. Multivariate analysis indicated that ≤4/6 HLA-matched W-CBUs led to lower leukemia-free survival (44% versus 56%; hazard ratio [HR], 1.5; P = .032) and overall survival (49% versus 62%; HR, 1.5; P = .028), increased nonrelapse mortality (26% versus 18%; HR, 1.9; P = .027), and acute graft-versus-host disease (46% versus 35%; HR, 1.7; P = .013). We were unable to predict unit dominance, but we demonstrated that outcomes were strongly influenced by the degree of HLA mismatch between W-CBU and recipient. Therefore, selection of both units with the lower number of HLA mismatches with the recipient is indicated.

KW - Double cord blood transplantation

KW - Winning cord blood unit

KW - Unit dominance

KW - Acute leukemia

KW - HLA

U2 - 10.1016/j.bbmt.2018.02.014

DO - 10.1016/j.bbmt.2018.02.014

M3 - Article

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

SN - 1083-8791

ER -