Control of nuclear receptor function by local chromatin structure

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Control of nuclear receptor function by local chromatin structure. / Wiench, Malgorzata; Miranda, TB; Hager, GL.

In: FEBS Journal, Vol. 278, No. 13, 01.07.2011, p. 2211-2230.

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Wiench, Malgorzata ; Miranda, TB ; Hager, GL. / Control of nuclear receptor function by local chromatin structure. In: FEBS Journal. 2011 ; Vol. 278, No. 13. pp. 2211-2230.

Bibtex

@article{4361f57440a644f2a214c114e8809e40,
title = "Control of nuclear receptor function by local chromatin structure",
abstract = "Steroid hormone receptors regulate gene transcription in a highly tissue-specific manner. The local chromatin structure underlying promoters and hormone response elements is a major component involved in controlling these highly restricted expression patterns. Chromatin remodeling complexes, as well as histone and DNA modifying enzymes, are directed to gene-specific regions and create permissive or repressive chromatin environments. These structures further enable proper communication between transcription factors, co-regulators and basic transcription machinery. The regulatory elements active at target genes can be either constitutively accessible to receptors or subject to rapid receptor-dependent modification. The chromatin states responsible for these processes are in turn determined during development and differentiation. Thus access of regulatory factors to elements in chromatin provides a major level of cell selective regulation.",
author = "Malgorzata Wiench and TB Miranda and GL Hager",
year = "2011",
month = jul
day = "1",
doi = "10.1111/j.1742-4658.2011.08126.x",
language = "English",
volume = "278",
pages = "2211--2230",
journal = "The FEBS journal",
issn = "1742-464X",
publisher = "Wiley",
number = "13",

}

RIS

TY - JOUR

T1 - Control of nuclear receptor function by local chromatin structure

AU - Wiench, Malgorzata

AU - Miranda, TB

AU - Hager, GL

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Steroid hormone receptors regulate gene transcription in a highly tissue-specific manner. The local chromatin structure underlying promoters and hormone response elements is a major component involved in controlling these highly restricted expression patterns. Chromatin remodeling complexes, as well as histone and DNA modifying enzymes, are directed to gene-specific regions and create permissive or repressive chromatin environments. These structures further enable proper communication between transcription factors, co-regulators and basic transcription machinery. The regulatory elements active at target genes can be either constitutively accessible to receptors or subject to rapid receptor-dependent modification. The chromatin states responsible for these processes are in turn determined during development and differentiation. Thus access of regulatory factors to elements in chromatin provides a major level of cell selective regulation.

AB - Steroid hormone receptors regulate gene transcription in a highly tissue-specific manner. The local chromatin structure underlying promoters and hormone response elements is a major component involved in controlling these highly restricted expression patterns. Chromatin remodeling complexes, as well as histone and DNA modifying enzymes, are directed to gene-specific regions and create permissive or repressive chromatin environments. These structures further enable proper communication between transcription factors, co-regulators and basic transcription machinery. The regulatory elements active at target genes can be either constitutively accessible to receptors or subject to rapid receptor-dependent modification. The chromatin states responsible for these processes are in turn determined during development and differentiation. Thus access of regulatory factors to elements in chromatin provides a major level of cell selective regulation.

U2 - 10.1111/j.1742-4658.2011.08126.x

DO - 10.1111/j.1742-4658.2011.08126.x

M3 - Article

C2 - 21501385

VL - 278

SP - 2211

EP - 2230

JO - The FEBS journal

JF - The FEBS journal

SN - 1742-464X

IS - 13

ER -