Contributions to our understanding of T cell physiology through unveiling the T cell proteome

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

Abstract

Since the sequencing of the human genome was completed, attention has turned to examining the functionality of the molecular machinery, in particular of protein expression. Differential proteome analysis by two-dimensional electrophoresis has been adopted to study changes in T cell proteomes during T cell activation, and this work is increasing our understanding of the complexity of signals elicited across multiple pathways. The purpose of this review is to summarize the available evidence in the application of proteomic techniques and methodologies to understand T cell receptor activation from lipid raft and cytoskeletal rearrangements, through to signalling cascades, transcription factor modulation and changes in protein expression patterns. These include post-translational modifications, which are not encoded by the genome.

Details

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalClinical & Experimental Immunology
Volume149
Issue number1
Publication statusPublished - 1 Jul 2007

Keywords

  • T cells, proteomics, 2D-PAGE