Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Colleges, School and Institutes

Abstract

The morphology of the pathognomonic Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma was described over a century ago, yet it was only relatively recently that the B-cell origin of these cells was identified. In a proportion of cases, HRS cells harbour monoclonal forms of the B lymphotropic Epstein-Barr virus (EBV). This review summarises current knowledge of the pathogenesis of Hodgkin lymphoma with a particular emphasis on the contribution of EBV.

Details

Original languageEnglish
Title of host publicationEpstein Barr Virus Volume 1
Subtitle of host publicationOne Herpes Virus: Many Diseases
EditorsChristian Münz
Publication statusPublished - 1 Oct 2015

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume390
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965