Contact mechanics of single particle compression and bulk compression of single component and binary mixtures of particles

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Contact mechanics of single particle compression and bulk compression of single component and binary mixtures of particles. / Yap, Siaw Fung; Seville, P. K Jonathan; Adams, Michael J.; Zhang, Zhibing.

AIChE Annual Meeting, Conference Proceedings. 2006.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Harvard

Yap, SF, Seville, PKJ, Adams, MJ & Zhang, Z 2006, Contact mechanics of single particle compression and bulk compression of single component and binary mixtures of particles. in AIChE Annual Meeting, Conference Proceedings. 2006 AIChE Spring National Meeting - 5th World Congress on Particle Technology, Orlando, FL, United States, 23/04/06.

APA

Vancouver

Author

Bibtex

@inproceedings{ec9412822f9d43b7a153f6338d8b6f73,
title = "Contact mechanics of single particle compression and bulk compression of single component and binary mixtures of particles",
abstract = "The compaction of particulate materials to make tablets is increasingly employed as a final dosage form for functional products due to its simplicity and low cost. However, the functionality of some products may be impaired due to the high compression pressures required. Pharmaceutical tablets generally consist of a number of components, which all contribute to the final properties of tablets. Therefore, it is of interest to be able to predict the compaction behaviour of powder mixtures based on the mechanical properties and compaction behaviour of individual components. However, this is a challenging task due to the complexity and diversity of pharmaceutical blends. Here, mixtures of two pharmaceutical excipients of different hardnesses were selected in order to investigate some of the controlling factors. The importance of the relative proportions of the ingredients has been studied in relation to the compactability of the respective single components.",
keywords = "Binary mixture, Compression, Mechanical properties, Micromanipulation, Particles",
author = "Yap, {Siaw Fung} and Seville, {P. K Jonathan} and Adams, {Michael J.} and Zhibing Zhang",
year = "2006",
language = "English",
booktitle = "AIChE Annual Meeting, Conference Proceedings",
note = "2006 AIChE Spring National Meeting - 5th World Congress on Particle Technology ; Conference date: 23-04-2006 Through 27-04-2006",

}

RIS

TY - GEN

T1 - Contact mechanics of single particle compression and bulk compression of single component and binary mixtures of particles

AU - Yap, Siaw Fung

AU - Seville, P. K Jonathan

AU - Adams, Michael J.

AU - Zhang, Zhibing

PY - 2006

Y1 - 2006

N2 - The compaction of particulate materials to make tablets is increasingly employed as a final dosage form for functional products due to its simplicity and low cost. However, the functionality of some products may be impaired due to the high compression pressures required. Pharmaceutical tablets generally consist of a number of components, which all contribute to the final properties of tablets. Therefore, it is of interest to be able to predict the compaction behaviour of powder mixtures based on the mechanical properties and compaction behaviour of individual components. However, this is a challenging task due to the complexity and diversity of pharmaceutical blends. Here, mixtures of two pharmaceutical excipients of different hardnesses were selected in order to investigate some of the controlling factors. The importance of the relative proportions of the ingredients has been studied in relation to the compactability of the respective single components.

AB - The compaction of particulate materials to make tablets is increasingly employed as a final dosage form for functional products due to its simplicity and low cost. However, the functionality of some products may be impaired due to the high compression pressures required. Pharmaceutical tablets generally consist of a number of components, which all contribute to the final properties of tablets. Therefore, it is of interest to be able to predict the compaction behaviour of powder mixtures based on the mechanical properties and compaction behaviour of individual components. However, this is a challenging task due to the complexity and diversity of pharmaceutical blends. Here, mixtures of two pharmaceutical excipients of different hardnesses were selected in order to investigate some of the controlling factors. The importance of the relative proportions of the ingredients has been studied in relation to the compactability of the respective single components.

KW - Binary mixture

KW - Compression

KW - Mechanical properties

KW - Micromanipulation

KW - Particles

UR - http://www.scopus.com/inward/record.url?scp=56749179204&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:56749179204

BT - AIChE Annual Meeting, Conference Proceedings

T2 - 2006 AIChE Spring National Meeting - 5th World Congress on Particle Technology

Y2 - 23 April 2006 through 27 April 2006

ER -