Consumer safety considerations of skin and oral microbiome perturbation

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Consumer safety considerations of skin and oral microbiome perturbation. / McBain, Andrew J; Chapple, Iain.

In: Clinical Microbiology Reviews, Vol. 32, No. 4, e00051-19, 10.2019.

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@article{9b3736eecbf047ba83298bf1c49de381,
title = "Consumer safety considerations of skin and oral microbiome perturbation",
abstract = "Microbiomes associated with human skin and the oral cavity are uniquely exposed to personal care regimes. Changes in the composition and activities of the microbial communities in these environments can be utilized to promote consumer health benefits, for example, by reducing the numbers, composition, or activities of microbes implicated in conditions such as acne, axillary odor, dandruff, and oral diseases. It is, however, important to ensure that innovative approaches for microbiome manipulation do not unsafely disrupt the microbiome or compromise health, and where major changes in the composition or activities of the microbiome may occur, these require evaluation to ensure that critical biological functions are unaffected. This article is based on a 2-day workshop held at SEAC Unilever, Sharnbrook, United Kingdom, involving 31 specialists in microbial risk assessment, skin and oral microbiome research, microbial ecology, bioinformatics, mathematical modeling, and immunology. The first day focused on understanding the potential implications of skin and oral microbiome perturbation, while approaches to characterize those perturbations were discussed during the second day. This article discusses the factors that the panel recommends be considered for personal care products that target the microbiomes of the skin and the oral cavity.",
keywords = "Consumer safety, Hygiene, Oral microbiome, Personal care, Risk assessment, Skin microbiome",
author = "McBain, {Andrew J} and Iain Chapple",
note = "Copyright {\textcopyright} 2019 American Society for Microbiology.",
year = "2019",
month = oct,
doi = "10.1128/CMR.00051-19",
language = "English",
volume = "32",
journal = "Clinical Microbiology Reviews",
issn = "0893-8512",
publisher = "American Society for Microbiology",
number = "4",

}

RIS

TY - JOUR

T1 - Consumer safety considerations of skin and oral microbiome perturbation

AU - McBain, Andrew J

AU - Chapple, Iain

N1 - Copyright © 2019 American Society for Microbiology.

PY - 2019/10

Y1 - 2019/10

N2 - Microbiomes associated with human skin and the oral cavity are uniquely exposed to personal care regimes. Changes in the composition and activities of the microbial communities in these environments can be utilized to promote consumer health benefits, for example, by reducing the numbers, composition, or activities of microbes implicated in conditions such as acne, axillary odor, dandruff, and oral diseases. It is, however, important to ensure that innovative approaches for microbiome manipulation do not unsafely disrupt the microbiome or compromise health, and where major changes in the composition or activities of the microbiome may occur, these require evaluation to ensure that critical biological functions are unaffected. This article is based on a 2-day workshop held at SEAC Unilever, Sharnbrook, United Kingdom, involving 31 specialists in microbial risk assessment, skin and oral microbiome research, microbial ecology, bioinformatics, mathematical modeling, and immunology. The first day focused on understanding the potential implications of skin and oral microbiome perturbation, while approaches to characterize those perturbations were discussed during the second day. This article discusses the factors that the panel recommends be considered for personal care products that target the microbiomes of the skin and the oral cavity.

AB - Microbiomes associated with human skin and the oral cavity are uniquely exposed to personal care regimes. Changes in the composition and activities of the microbial communities in these environments can be utilized to promote consumer health benefits, for example, by reducing the numbers, composition, or activities of microbes implicated in conditions such as acne, axillary odor, dandruff, and oral diseases. It is, however, important to ensure that innovative approaches for microbiome manipulation do not unsafely disrupt the microbiome or compromise health, and where major changes in the composition or activities of the microbiome may occur, these require evaluation to ensure that critical biological functions are unaffected. This article is based on a 2-day workshop held at SEAC Unilever, Sharnbrook, United Kingdom, involving 31 specialists in microbial risk assessment, skin and oral microbiome research, microbial ecology, bioinformatics, mathematical modeling, and immunology. The first day focused on understanding the potential implications of skin and oral microbiome perturbation, while approaches to characterize those perturbations were discussed during the second day. This article discusses the factors that the panel recommends be considered for personal care products that target the microbiomes of the skin and the oral cavity.

KW - Consumer safety

KW - Hygiene

KW - Oral microbiome

KW - Personal care

KW - Risk assessment

KW - Skin microbiome

UR - http://www.scopus.com/inward/record.url?scp=85070899228&partnerID=8YFLogxK

U2 - 10.1128/CMR.00051-19

DO - 10.1128/CMR.00051-19

M3 - Review article

C2 - 31366612

VL - 32

JO - Clinical Microbiology Reviews

JF - Clinical Microbiology Reviews

SN - 0893-8512

IS - 4

M1 - e00051-19

ER -