Construction of DNA-polymer hybrids using intercalation interactions

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy.

Details

Original languageEnglish
Pages (from-to)1338-1340
JournalChemical Communications
Volume50
Publication statusPublished - 2014