Construction of DNA-polymer hybrids using intercalation interactions

Thomas R. Wilks; Anais Pitto-Barry; Nigel Kirby; Eugen Stulz; Rachel K. O'Reilly

doi:10.1039/c3cc48726a

Construction of DNA-polymer hybrids using intercalation interactions

Thomas R. Wilks, Anais Pitto-Barry, Nigel Kirby, Eugen Stulz, Rachel K. O'Reilly

Chemistry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy.

Original language	English
Pages (from-to)	1338-1340
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	11
Early online date	17 Dec 2013
DOIs	https://doi.org/10.1039/c3cc48726a
Publication status	Published - 2014

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AB - Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy.

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Construction of DNA-polymer hybrids using intercalation interactions

Abstract

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