Construction of DNA-polymer hybrids using intercalation interactions

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Colleges, School and Institutes


Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy.


Original languageEnglish
Pages (from-to)1338-1340
Number of pages3
JournalChemical Communications
Issue number11
Early online date17 Dec 2013
Publication statusPublished - 2014