Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample

Research output: Contribution to journalArticle

Authors

  • Jennifer B Dowd
  • Adrian Loerbroks
  • Marc N Jarczok
  • Tobias Stalder
  • Kristina Hoffman
  • Joachim E Fischer
  • Jos A Bosch

External organisations

  • CUNY School of Public Health and CUNY Institute for Demographic Research (CIDR), One Bernard Baruch Way, New York, NY 10010, USA.
  • Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH), Mannheim Medical Faculty, University of Heidelberg, Ludolf-Krehl-Str. 7-11, D-68167 Mannheim, Germany; Institute for Medical Sociology, University Hospital Düsseldorf, Universität Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
  • Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH), Mannheim Medical Faculty, University of Heidelberg, Ludolf-Krehl-Str. 7-11, D-68167 Mannheim, Germany.
  • Department of Psychology, Technische Universität Dresden, 01069 Dresden, Germany.
  • Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH), Mannheim Medical Faculty, University of Heidelberg, Ludolf-Krehl-Str. 7-11, D-68167 Mannheim, Germany; Department of Psychology, University of Amsterdam, Weesperplein 4, 1018 XA Amsterdam, The Netherlands. Electronic address: j.a.bosch@uva.nl.

Abstract

Cytomegalovirus (CMV) is a herpes virus that has been implicated in biological aging and impaired health. Evidence, largely accrued from small-scale studies involving select populations, suggests that stress may promote non-clinical reactivation of this virus. However, absent is evidence from larger studies, which allow better statistical adjustment for confounding and mediating factors, in more representative samples. The present study involved a large occupational cohort (N=887, mean age=44, 88% male). Questionnaires assessed psychological (i.e., depression, anxiety, vital exhaustion, SF-12 mental health), demographic, socioeconomic (SES), and lifestyle variables. Plasma samples were analyzed for both the presence and level of CMV-specific IgG antibodies (CMV-IgG), used as markers for infection status and viral reactivation, respectively. Also assessed were potential biological mediators of stress-induced reactivation, such as inflammation (C-reactive protein) and HPA function (awakening and diurnal cortisol). Predictors of CMV infection and CMV-IgG among the infected individuals were analyzed using logistic and linear regression analyses, respectively. Confirming prior reports, lower SES (education and job status) was positively associated with infection status. Among those infected (N=329), higher CMV-IgG were associated with increased anxiety (β=.14, p

Bibliographic note

Copyright © 2014. Published by Elsevier Inc.

Details

Original languageEnglish
JournalBrain, Behaviour, and Immunity
Publication statusPublished - 26 Jan 2014