Conjugated Linoleic Acid Impairs Endothelial Function

JS Taylor; SR Williams; R Rhys; P James; Michael Frenneaux

doi:10.1161/01.ATV.0000199679.40501.ac

Conjugated Linoleic Acid Impairs Endothelial Function

JS Taylor, SR Williams, R Rhys, P James, Michael Frenneaux

Birmingham Medical School

Research output: Contribution to journal › Article

80 Citations (Scopus)

Abstract

OBJECTIVE: To determine the effect of dietary supplementation with conjugated linoleic acid (CLA) on body mass index (BMI), body fat distribution, endothelial function, and markers of cardiovascular risk. METHODS AND RESULTS: Forty healthy volunteers with BMI >27 kg/m2 were randomized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study. Subcutaneous body fat and abdominal/hepatic fat content were assessed using skin-fold thicknesses and computed tomography scanning, respectively. Endothelial function was assessed by brachial artery flow-mediated dilatation (FMD). Plasma isoprostanes were measured as an index of oxidative stress. CLA supplementation did not result in a significant change in BMI index or total body fat. There was a significant decrease in limb (-7.8 mm, P

Original language	English
Pages (from-to)	307-312
Number of pages	6
Journal	Arteriosclerosis Thrombosis and Vascular Biology
Volume	26
Issue number	2
Early online date	1 Dec 2005
DOIs	https://doi.org/10.1161/01.ATV.0000199679.40501.ac
Publication status	Published - 1 Dec 2005

Keywords

endothelial function
body composition
obesity
conjugated linoleic acid
oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/01.ATV.0000199679.40501.ac

Cite this

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T1 - Conjugated Linoleic Acid Impairs Endothelial Function

AU - Taylor, JS

AU - Williams, SR

AU - Rhys, R

AU - James, P

AU - Frenneaux, Michael

PY - 2005/12/1

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AB - OBJECTIVE: To determine the effect of dietary supplementation with conjugated linoleic acid (CLA) on body mass index (BMI), body fat distribution, endothelial function, and markers of cardiovascular risk. METHODS AND RESULTS: Forty healthy volunteers with BMI >27 kg/m2 were randomized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study. Subcutaneous body fat and abdominal/hepatic fat content were assessed using skin-fold thicknesses and computed tomography scanning, respectively. Endothelial function was assessed by brachial artery flow-mediated dilatation (FMD). Plasma isoprostanes were measured as an index of oxidative stress. CLA supplementation did not result in a significant change in BMI index or total body fat. There was a significant decrease in limb (-7.8 mm, P

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KW - body composition

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KW - conjugated linoleic acid

KW - oxidative stress

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Conjugated Linoleic Acid Impairs Endothelial Function

Abstract

Keywords

UN SDGs

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