Conduit artery diameter during exercise is enhanced after local, but not remote, ischemic preconditioning

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Conduit artery diameter during exercise is enhanced after local, but not remote, ischemic preconditioning. / Cocking, Scott; Cable, N. T.; Wilson, Mathew G.; Green, Daniel J.; Thijssen, Dick H.J.; Jones, Helen.

In: Frontiers in Physiology, Vol. 9, 435, 24.04.2018.

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Cocking, Scott ; Cable, N. T. ; Wilson, Mathew G. ; Green, Daniel J. ; Thijssen, Dick H.J. ; Jones, Helen. / Conduit artery diameter during exercise is enhanced after local, but not remote, ischemic preconditioning. In: Frontiers in Physiology. 2018 ; Vol. 9.

Bibtex

@article{3c4ef336fa3e49f99360f948dec7efa0,
title = "Conduit artery diameter during exercise is enhanced after local, but not remote, ischemic preconditioning",
abstract = "Introduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decreases in vascular function following exercise. Methods: Eighteen healthy, recreationally trained, male participants (mean ±SD: age 32 ± 8 years; BMI 24.2 ± 2.3; blood pressure 122 ± 10/72 ± 8 mmHg; resting HR 58 ± 9 beats min-1) received IPC (220 mmHg; 4 × 5-min bilateral arms), REMOTE IPC (220 mmHg; 4 × 5-min bilateral legs), or SHAM (20 mmHg; 4 × 5-min bilateral arms) in a counterbalanced order prior to 30-min of submaximal (25% maximal voluntary contraction) unilateral rhythmic handgrip exercise. Brachial artery diameter and blood flow were assessed every 5-min throughout the 30-min submaximal exercise using high resolution ultrasonography. Pre- and post-exercise vascular function was measured using flow-mediated dilation (FMD). Results: IPC resulted in enlarged brachial artery diameter during exercise [0.016 cm (0.003-0.03 cm), P = 0.015] compared to REMOTE IPC, but blood flow during exercise was similar between conditions (P > 0.05). Blood flow (l/min) increased throughout exercise (time: P < 0.005), but there was no main effect of condition (P = 0.29) or condition * time interaction (P = 0.83). Post-exercise FMD was similar between conditions (P > 0.05). Conclusion: Our data show that local (but not remote) IPC, performed as a strategy prior to exercise, enhanced exercise-induced conduit artery diameter dilation, but these changes do not translate into increased blood flow during exercise nor impact post-exercise vascular function.",
keywords = "Blood flow, Cardiovascular, Endothelial function, Handgrip exercise, Ischemic preconditioning",
author = "Scott Cocking and Cable, {N. T.} and Wilson, {Mathew G.} and Green, {Daniel J.} and Thijssen, {Dick H.J.} and Helen Jones",
note = "Cocking S, Cable NT, Wilson MG, Green DJ, Thijssen DHJ and Jones H (2018) Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning. Front. Physiol. 9:435. doi: 10.3389/fphys.2018.00435",
year = "2018",
month = apr,
day = "24",
doi = "10.3389/fphys.2018.00435",
language = "English",
volume = "9",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers",

}

RIS

TY - JOUR

T1 - Conduit artery diameter during exercise is enhanced after local, but not remote, ischemic preconditioning

AU - Cocking, Scott

AU - Cable, N. T.

AU - Wilson, Mathew G.

AU - Green, Daniel J.

AU - Thijssen, Dick H.J.

AU - Jones, Helen

N1 - Cocking S, Cable NT, Wilson MG, Green DJ, Thijssen DHJ and Jones H (2018) Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning. Front. Physiol. 9:435. doi: 10.3389/fphys.2018.00435

PY - 2018/4/24

Y1 - 2018/4/24

N2 - Introduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decreases in vascular function following exercise. Methods: Eighteen healthy, recreationally trained, male participants (mean ±SD: age 32 ± 8 years; BMI 24.2 ± 2.3; blood pressure 122 ± 10/72 ± 8 mmHg; resting HR 58 ± 9 beats min-1) received IPC (220 mmHg; 4 × 5-min bilateral arms), REMOTE IPC (220 mmHg; 4 × 5-min bilateral legs), or SHAM (20 mmHg; 4 × 5-min bilateral arms) in a counterbalanced order prior to 30-min of submaximal (25% maximal voluntary contraction) unilateral rhythmic handgrip exercise. Brachial artery diameter and blood flow were assessed every 5-min throughout the 30-min submaximal exercise using high resolution ultrasonography. Pre- and post-exercise vascular function was measured using flow-mediated dilation (FMD). Results: IPC resulted in enlarged brachial artery diameter during exercise [0.016 cm (0.003-0.03 cm), P = 0.015] compared to REMOTE IPC, but blood flow during exercise was similar between conditions (P > 0.05). Blood flow (l/min) increased throughout exercise (time: P < 0.005), but there was no main effect of condition (P = 0.29) or condition * time interaction (P = 0.83). Post-exercise FMD was similar between conditions (P > 0.05). Conclusion: Our data show that local (but not remote) IPC, performed as a strategy prior to exercise, enhanced exercise-induced conduit artery diameter dilation, but these changes do not translate into increased blood flow during exercise nor impact post-exercise vascular function.

AB - Introduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decreases in vascular function following exercise. Methods: Eighteen healthy, recreationally trained, male participants (mean ±SD: age 32 ± 8 years; BMI 24.2 ± 2.3; blood pressure 122 ± 10/72 ± 8 mmHg; resting HR 58 ± 9 beats min-1) received IPC (220 mmHg; 4 × 5-min bilateral arms), REMOTE IPC (220 mmHg; 4 × 5-min bilateral legs), or SHAM (20 mmHg; 4 × 5-min bilateral arms) in a counterbalanced order prior to 30-min of submaximal (25% maximal voluntary contraction) unilateral rhythmic handgrip exercise. Brachial artery diameter and blood flow were assessed every 5-min throughout the 30-min submaximal exercise using high resolution ultrasonography. Pre- and post-exercise vascular function was measured using flow-mediated dilation (FMD). Results: IPC resulted in enlarged brachial artery diameter during exercise [0.016 cm (0.003-0.03 cm), P = 0.015] compared to REMOTE IPC, but blood flow during exercise was similar between conditions (P > 0.05). Blood flow (l/min) increased throughout exercise (time: P < 0.005), but there was no main effect of condition (P = 0.29) or condition * time interaction (P = 0.83). Post-exercise FMD was similar between conditions (P > 0.05). Conclusion: Our data show that local (but not remote) IPC, performed as a strategy prior to exercise, enhanced exercise-induced conduit artery diameter dilation, but these changes do not translate into increased blood flow during exercise nor impact post-exercise vascular function.

KW - Blood flow

KW - Cardiovascular

KW - Endothelial function

KW - Handgrip exercise

KW - Ischemic preconditioning

UR - http://www.scopus.com/inward/record.url?scp=85045902553&partnerID=8YFLogxK

U2 - 10.3389/fphys.2018.00435

DO - 10.3389/fphys.2018.00435

M3 - Article

AN - SCOPUS:85045902553

VL - 9

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 435

ER -