Concentrations of perfluoroalkyl substances in human milk from Ireland: Implications for adult and nursing infant exposure

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Concentrations of perfluoroalkyl substances in human milk from Ireland: Implications for adult and nursing infant exposure. / Abdallah, Mohamed; Wemken, Nina; Drage, Daniel; Cellarius, Claire; Cleere, Kathy; Morrison, John; Daly, Sean; Coggins, Marie; Harrad, Stuart.

In: Chemosphere, Vol. 246, 125724, 05.2020.

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Abdallah, Mohamed ; Wemken, Nina ; Drage, Daniel ; Cellarius, Claire ; Cleere, Kathy ; Morrison, John ; Daly, Sean ; Coggins, Marie ; Harrad, Stuart. / Concentrations of perfluoroalkyl substances in human milk from Ireland: Implications for adult and nursing infant exposure. In: Chemosphere. 2020 ; Vol. 246.

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@article{dbda559ba4074a2e8b1d7fb484cf363a,
title = "Concentrations of perfluoroalkyl substances in human milk from Ireland: Implications for adult and nursing infant exposure",
abstract = "Concentrations of 10 perfluoroalkyl substances (PFASs) were measured in 16 pools of human milk from Ireland. Only four PFASs were detected (PFOA, PFNA, PFHxS and PFOS), with concentrations dominated by PFOA which was detected in all samples at a median of 0.10 ng/mL. Concentrations and the relative abundance of PFASs in human milk from Ireland are within the range reported for other countries. Estimated exposures for nursing infants to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) do not suggest a health concern. A one compartment pharmacokinetic model was used to predictthe intakes of PFOS and PFOA required to support the observed concentrations in human milk. This suggests current adult exposure in Ireland to PFOS is below the provisional tolerable weekly intake (TWI) proposed by EFSA. In contrast, the model predicts that the maximum concentration detected in humanmilk in this study, implies a level of adult exposure that would exceed EFSA{\textquoteright}s provisional TWI for PFOA. As exposure of the Irish population to PFASs via drinking water, indoor air and dust is well-characterised, current understanding suggests that the major contributor to overall exposure of the Irish population isvia the diet and/or less well-studied pathways like dermal uptake from PFAS-containing fabrics and cosmetics.",
keywords = "Human biomonitoring, PFASs, PK modelling, PFOS, PFOA",
author = "Mohamed Abdallah and Nina Wemken and Daniel Drage and Claire Cellarius and Kathy Cleere and John Morrison and Sean Daly and Marie Coggins and Stuart Harrad",
year = "2020",
month = may,
doi = "10.1016/j.chemosphere.2019.125724",
language = "English",
volume = "246",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Concentrations of perfluoroalkyl substances in human milk from Ireland: Implications for adult and nursing infant exposure

AU - Abdallah, Mohamed

AU - Wemken, Nina

AU - Drage, Daniel

AU - Cellarius, Claire

AU - Cleere, Kathy

AU - Morrison, John

AU - Daly, Sean

AU - Coggins, Marie

AU - Harrad, Stuart

PY - 2020/5

Y1 - 2020/5

N2 - Concentrations of 10 perfluoroalkyl substances (PFASs) were measured in 16 pools of human milk from Ireland. Only four PFASs were detected (PFOA, PFNA, PFHxS and PFOS), with concentrations dominated by PFOA which was detected in all samples at a median of 0.10 ng/mL. Concentrations and the relative abundance of PFASs in human milk from Ireland are within the range reported for other countries. Estimated exposures for nursing infants to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) do not suggest a health concern. A one compartment pharmacokinetic model was used to predictthe intakes of PFOS and PFOA required to support the observed concentrations in human milk. This suggests current adult exposure in Ireland to PFOS is below the provisional tolerable weekly intake (TWI) proposed by EFSA. In contrast, the model predicts that the maximum concentration detected in humanmilk in this study, implies a level of adult exposure that would exceed EFSA’s provisional TWI for PFOA. As exposure of the Irish population to PFASs via drinking water, indoor air and dust is well-characterised, current understanding suggests that the major contributor to overall exposure of the Irish population isvia the diet and/or less well-studied pathways like dermal uptake from PFAS-containing fabrics and cosmetics.

AB - Concentrations of 10 perfluoroalkyl substances (PFASs) were measured in 16 pools of human milk from Ireland. Only four PFASs were detected (PFOA, PFNA, PFHxS and PFOS), with concentrations dominated by PFOA which was detected in all samples at a median of 0.10 ng/mL. Concentrations and the relative abundance of PFASs in human milk from Ireland are within the range reported for other countries. Estimated exposures for nursing infants to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) do not suggest a health concern. A one compartment pharmacokinetic model was used to predictthe intakes of PFOS and PFOA required to support the observed concentrations in human milk. This suggests current adult exposure in Ireland to PFOS is below the provisional tolerable weekly intake (TWI) proposed by EFSA. In contrast, the model predicts that the maximum concentration detected in humanmilk in this study, implies a level of adult exposure that would exceed EFSA’s provisional TWI for PFOA. As exposure of the Irish population to PFASs via drinking water, indoor air and dust is well-characterised, current understanding suggests that the major contributor to overall exposure of the Irish population isvia the diet and/or less well-studied pathways like dermal uptake from PFAS-containing fabrics and cosmetics.

KW - Human biomonitoring

KW - PFASs

KW - PK modelling

KW - PFOS

KW - PFOA

U2 - 10.1016/j.chemosphere.2019.125724

DO - 10.1016/j.chemosphere.2019.125724

M3 - Article

VL - 246

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

M1 - 125724

ER -