Computational study of ATP gated Potassium ion channel in urinary bladder over activity

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Authors

Colleges, School and Institutes

External organisations

  • Indian Inst Technol

Abstract

Enhanced spontaneous electrical activity in detrusor smooth muscle cell is a major cause of over active bladder. ATP sensitive Potassium channel, which may play a crucial part in modulating resting membrane potential of detrusor smooth muscle cell and hence in bladder over activity. The main objective of our study is to construct a computational model of ATP sensitive Potassium channel in DSM cell with sufficient biophysical details to investigate its' modulating role in electrical excitability. The model was based on documented electrophysiological data in published experimental studies. We have validated our simulated ATP sensitive Potassium ion channel current by comparing with experimental recordings and it showed positive agreements in numerous parameters. At the present time, our computational model provides an elementary tool to analyze the physiological role of ATP sensitive Potassium ionic current in detrusor smooth muscle electrical activity underlying the contractions in DSM cells that successively will shed light in genesis of bladder overactivity.

Details

Original languageEnglish
Title of host publication2016 International Conference on Inventive Computation Technologies (ICICT)
Publication statusPublished - 19 Jan 2017
EventInternational Conference on Inventive Computer Technologies, 2016 - Coimbatore, India
Duration: 26 Aug 201627 Aug 2016

Conference

ConferenceInternational Conference on Inventive Computer Technologies, 2016
Abbreviated titleICICT 2016
CountryIndia
CityCoimbatore
Period26/08/1627/08/16

ASJC Scopus subject areas