Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease

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Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease. / Hall, Caitlin; Gehmlich, Katja; Denning, Chris; Pavlovic, Davor.

In: Journal of the American Heart Association, Vol. 10, No. 5, e019338, 02.03.2021.

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@article{4f5ca27fc7fa48b88654541275447e3b,
title = "Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease",
abstract = "Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐to‐myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.",
keywords = "Arrhythmias, Cardiac fibroblasts, Cardiomyocytes, Fibrosis, Heart failure, Myofibroblast",
author = "Caitlin Hall and Katja Gehmlich and Chris Denning and Davor Pavlovic",
note = "Funding Information: This work was supported by the British Heart Foundation grants (PG/17/55/33087, RG/17/15/33106, FS/19/12/34204, and FS/19/16/34169 to Dr Pavlovic; SP/15/9/31605, PG/14/59/31000, RG/14/1/30588, RM/13/30157, and P47352/CRM to Dr Denning; and FS/12/40/29712 to Dr Gehmlich); the Wellcome Trust Grants (109604/Z/15/Z to Dr Pavlovic and 201543/B/16/Z to Dr Gehmlich); Animal Free Research UK (AFR19-20293 to Drs Pavlovic and Denning); National Centre for the Replacement, Refinement, and Reduction of Animals in Research (CRACK-IT:35911-259146 and NC/K000225/1 to Dr Denning and NC/T001747/1 to Dr Gehmlich); Accelerator Award (AA/18/2/34218) to Institute of Cardiovascular Sciences at Birmingham; and Oxford British Heart Foundation Centre of Research Excellence (RE/13/1/30181). Publisher Copyright: {\textcopyright} 2021 The Authors.",
year = "2021",
month = mar,
day = "2",
doi = "10.1161/JAHA.120.019338",
language = "English",
volume = "10",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "American Heart Association",
number = "5",

}

RIS

TY - JOUR

T1 - Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease

AU - Hall, Caitlin

AU - Gehmlich, Katja

AU - Denning, Chris

AU - Pavlovic, Davor

N1 - Funding Information: This work was supported by the British Heart Foundation grants (PG/17/55/33087, RG/17/15/33106, FS/19/12/34204, and FS/19/16/34169 to Dr Pavlovic; SP/15/9/31605, PG/14/59/31000, RG/14/1/30588, RM/13/30157, and P47352/CRM to Dr Denning; and FS/12/40/29712 to Dr Gehmlich); the Wellcome Trust Grants (109604/Z/15/Z to Dr Pavlovic and 201543/B/16/Z to Dr Gehmlich); Animal Free Research UK (AFR19-20293 to Drs Pavlovic and Denning); National Centre for the Replacement, Refinement, and Reduction of Animals in Research (CRACK-IT:35911-259146 and NC/K000225/1 to Dr Denning and NC/T001747/1 to Dr Gehmlich); Accelerator Award (AA/18/2/34218) to Institute of Cardiovascular Sciences at Birmingham; and Oxford British Heart Foundation Centre of Research Excellence (RE/13/1/30181). Publisher Copyright: © 2021 The Authors.

PY - 2021/3/2

Y1 - 2021/3/2

N2 - Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐to‐myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.

AB - Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐to‐myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.

KW - Arrhythmias

KW - Cardiac fibroblasts

KW - Cardiomyocytes

KW - Fibrosis

KW - Heart failure

KW - Myofibroblast

UR - http://www.scopus.com/inward/record.url?scp=85102535849&partnerID=8YFLogxK

U2 - 10.1161/JAHA.120.019338

DO - 10.1161/JAHA.120.019338

M3 - Article

C2 - 33586463

VL - 10

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 5

M1 - e019338

ER -