Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro

Research output: Contribution to journalArticlepeer-review


  • R Anderson
  • H C Steel
  • R Cockeran
  • A von Gottberg
  • L de Gouveia
  • K P Klugman
  • C Feldman

Colleges, School and Institutes


To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production by a macrolide-susceptible strain and two macrolide-resistant strains [erm(B) or mef(A)] of Streptococcus pneumoniae.


Original languageEnglish
Pages (from-to)1155-8
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Issue number5
Publication statusPublished - Nov 2007


  • Amoxicillin, Anti-Bacterial Agents, Bacterial Proteins, Ceftriaxone, Doxycycline, Drug Resistance, Multiple, Bacterial, Fluoroquinolones, Macrolides, Microbial Sensitivity Tests, Streptococcus pneumoniae, Streptolysins, Tobramycin