Comparison of neurological NIRS signals during standing Valsalva maneuvers, pre and post vasoconstrictor injection

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Comparison of neurological NIRS signals during standing Valsalva maneuvers, pre and post vasoconstrictor injection. / Clancy, Michael; Belli, Antonio; Davies, David; Lucas, Samuel J E; Su, Zhangjie; Dehghani, Hamid.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9538 Society of Photo-Optical Instrumentation Engineers, 2015. 953817.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Harvard

Clancy, M, Belli, A, Davies, D, Lucas, SJE, Su, Z & Dehghani, H 2015, Comparison of neurological NIRS signals during standing Valsalva maneuvers, pre and post vasoconstrictor injection. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9538, 953817, Society of Photo-Optical Instrumentation Engineers, Diffuse Optical Imaging V, Munich, Germany, 23/06/15. https://doi.org/10.1117/12.2183796

APA

Clancy, M., Belli, A., Davies, D., Lucas, S. J. E., Su, Z., & Dehghani, H. (2015). Comparison of neurological NIRS signals during standing Valsalva maneuvers, pre and post vasoconstrictor injection. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9538). [953817] Society of Photo-Optical Instrumentation Engineers. https://doi.org/10.1117/12.2183796

Vancouver

Clancy M, Belli A, Davies D, Lucas SJE, Su Z, Dehghani H. Comparison of neurological NIRS signals during standing Valsalva maneuvers, pre and post vasoconstrictor injection. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9538. Society of Photo-Optical Instrumentation Engineers. 2015. 953817 https://doi.org/10.1117/12.2183796

Author

Bibtex

@inproceedings{e5822fec02424ddeb001a95cbacbc2c3,
title = "Comparison of neurological NIRS signals during standing Valsalva maneuvers, pre and post vasoconstrictor injection",
abstract = "Near infrared spectroscopy (NIRS) has potential to offer a fast and non-invasive method of assessing cerebral saturation in a clinical setting, however, there are concerns that NIRS brain measures suffer contamination from superficial tissues. This study used the Valsalva manoeuver (VM) to determine whether NIRS could differentiate between superficial (from somatic tissue) and neurological changes in the context of traumatic brain injury. A potent vasopressor was used to assess the effect of reducing total haemoglobin concentration in the superficial regions of the forehead. Frequency domain NIRS measurements during the VM pre and post vasoconstrictor injection, combined with simulation data, conclusively show that NIRS can detect neurological changes, in both haemoglobin content and saturation, when positioned on the forehead. The effect of superficial contamination in this instance appeared to be insignificant, with no statistically significant change in saturation over 8 patients, even with a drop in superficial haemoglobin concentration due to the vasoconstrictor, confirmed by laser Doppler. Nevertheless, simulations indicated that the absolute values of the recovered NIRS parameters are not quantitatively accurate; however a direct comparison with invasive measures is needed to confirm this.",
author = "Michael Clancy and Antonio Belli and David Davies and Lucas, {Samuel J E} and Zhangjie Su and Hamid Dehghani",
year = "2015",
doi = "10.1117/12.2183796",
language = "English",
isbn = "9781628417036",
volume = "9538",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "Society of Photo-Optical Instrumentation Engineers",
address = "United States",

}

RIS

TY - GEN

T1 - Comparison of neurological NIRS signals during standing Valsalva maneuvers, pre and post vasoconstrictor injection

AU - Clancy, Michael

AU - Belli, Antonio

AU - Davies, David

AU - Lucas, Samuel J E

AU - Su, Zhangjie

AU - Dehghani, Hamid

PY - 2015

Y1 - 2015

N2 - Near infrared spectroscopy (NIRS) has potential to offer a fast and non-invasive method of assessing cerebral saturation in a clinical setting, however, there are concerns that NIRS brain measures suffer contamination from superficial tissues. This study used the Valsalva manoeuver (VM) to determine whether NIRS could differentiate between superficial (from somatic tissue) and neurological changes in the context of traumatic brain injury. A potent vasopressor was used to assess the effect of reducing total haemoglobin concentration in the superficial regions of the forehead. Frequency domain NIRS measurements during the VM pre and post vasoconstrictor injection, combined with simulation data, conclusively show that NIRS can detect neurological changes, in both haemoglobin content and saturation, when positioned on the forehead. The effect of superficial contamination in this instance appeared to be insignificant, with no statistically significant change in saturation over 8 patients, even with a drop in superficial haemoglobin concentration due to the vasoconstrictor, confirmed by laser Doppler. Nevertheless, simulations indicated that the absolute values of the recovered NIRS parameters are not quantitatively accurate; however a direct comparison with invasive measures is needed to confirm this.

AB - Near infrared spectroscopy (NIRS) has potential to offer a fast and non-invasive method of assessing cerebral saturation in a clinical setting, however, there are concerns that NIRS brain measures suffer contamination from superficial tissues. This study used the Valsalva manoeuver (VM) to determine whether NIRS could differentiate between superficial (from somatic tissue) and neurological changes in the context of traumatic brain injury. A potent vasopressor was used to assess the effect of reducing total haemoglobin concentration in the superficial regions of the forehead. Frequency domain NIRS measurements during the VM pre and post vasoconstrictor injection, combined with simulation data, conclusively show that NIRS can detect neurological changes, in both haemoglobin content and saturation, when positioned on the forehead. The effect of superficial contamination in this instance appeared to be insignificant, with no statistically significant change in saturation over 8 patients, even with a drop in superficial haemoglobin concentration due to the vasoconstrictor, confirmed by laser Doppler. Nevertheless, simulations indicated that the absolute values of the recovered NIRS parameters are not quantitatively accurate; however a direct comparison with invasive measures is needed to confirm this.

UR - http://www.scopus.com/inward/record.url?scp=84939833337&partnerID=8YFLogxK

U2 - 10.1117/12.2183796

DO - 10.1117/12.2183796

M3 - Conference contribution

AN - SCOPUS:84939833337

SN - 9781628417036

VL - 9538

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

PB - Society of Photo-Optical Instrumentation Engineers

ER -