Comparison of international normalised ratio audit parameters in patients enrolled in GARFIELD-AF and treated with vitamin K antagonists

Research output: Contribution to journalArticlepeer-review


  • GARFIELD-AF Investigators


Vitamin K antagonist (VKA) therapy for stroke prevention in atrial fibrillation (AF) requires monitoring of international normalised ratio (INR). We evaluated the agreement between two INR audit parameters, frequency in range (FIR) and proportion of time in the therapeutic range (TTR), using data from a global population of patients with newly diagnosed nonvalvular AF, the Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELDAF). Among 17,168 patients with 1-year follow-up data available at the time of the analysis, 8445 received VKA therapy (±antiplatelet therapy) at enrolment, and of these patients, 5066 with ≥3 INR readings and for whom FIR and TTR could both be calculated were included in the analysis. In total, 70,905 INRs were analysed. At the patient level, TTR showed higher values than FIR (mean, 56.0% vs 49.8%; median, 59.7% vs 50.0%). Although patient-level FIR and TTR values were highly correlated (Pearson correlation coefficient [95% confidence interval; CI], 0.860 [0.852 to 0.867]), estimates from individuals showed widespread disagreement and variability (Lin’s concordance coefficient [95% CI], 0.829 [0.821 to 0.837]). The difference between FIR and TTR explained 17.4% of the total variability of measurements. These results suggest that FIR and TTR are not equivalent and cannot be used interchangeably.


Original languageEnglish
JournalBritish Journal of Haematology
Early online date12 Apr 2016
Publication statusE-pub ahead of print - 12 Apr 2016


  • atrial fibrillation, frequency in range, international normalized ratio, time in therapeutic range, vitamin K antagonists