Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • University of Cambridge
  • THE UNIVERSITY OF WARWICK
  • Sensapharm Ltd.
  • THE UNIVERSITY OF WARWICK

Abstract

In parts of Africa and Asia, self-medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine-sensitive and -resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC50 values (>200 mm). The combination of artemisinin and 3-caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5-fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.

Details

Original languageEnglish
Pages (from-to)2791-2797
Number of pages7
JournalChemMedChem
Volume9
Issue number12
Early online date10 Sep 2014
Publication statusPublished - Dec 2014

Keywords

  • Antagonism, Artemisia tea, Artemisinin, Chlorogenic acid, Cisplatin, Synergy